Evidence map›Paper›PMID 37090796›Full record

ArticleFrontiers in neuroscience2023

The anti-inflammatory effects of photobiomodulation are mediated by cytokines: Evidence from a mouse model of inflammation.

Shirin Shamloo, Erwin Defensor, Peter Ciari, Gaku Ogawa, Laura Vidano, Jennifer S Lin, John A Fortkort, Mehrdad Shamloo, Annelise E Barron

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 56 citations in OpenAlex.

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  12. Treatments in oral lichen planus: a review.Frontiers in oral health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Shirin ShamlooDepartment of Bioengineering, Schools of Medicine and Engineering, Stanford University, Stanford, CA, United States.
Erwin DefensorDepartment of Bioengineering, Schools of Medicine and Engineering, Stanford University, Stanford, CA, United States.
Peter CiariDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, United States.
Gaku OgawaDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, United States.
Laura VidanoDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, United States.
Jennifer S LinDepartment of Bioengineering, Schools of Medicine and Engineering, Stanford University, Stanford, CA, United States.
John A FortkortDepartment of Bioengineering, Schools of Medicine and Engineering, Stanford University, Stanford, CA, United States.
Mehrdad ShamlooDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, United States.
Annelise E BarronDepartment of Bioengineering, Schools of Medicine and Engineering, Stanford University, Stanford, CA, United States.
Stanford University · US

Funding

Role of Innate Immune Dysregulation in the Etiology of DementiaDP1AG072438 · NIA · STANFORD UNIVERSITY · PI BARRON, ANNELISE EMILY · 2020 to 2024
$5.2M
NIA NIH HHS DP1 AG072438
6 · The paper itself

Abstract

There is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and prevent neuronal degeneration. Photobiomodulation (PBM), the therapeutic use of specific wavelengths of light, is a safe approach shown to have anti-inflammatory effects. The current study was aimed at evaluating the effects of PBM on LPS-induced peripheral and central inflammation in mice to assess its potential as an anti-inflammatory treatment. Daily, 30-min treatment of mice with red/NIR light (RL) or RL with a 40 Hz gamma frequency flicker for 10 days prior to LPS challenge showed anti-inflammatory effects in the brain and systemically. PBM downregulated LPS induction of key proinflammatory cytokines associated with inflammasome activation, IL-1β and IL-18, and upregulated the anti-inflammatory cytokine, IL-10. RL provided robust anti-inflammatory effects, and the addition of gamma flicker potentiated these effects. Overall, these results demonstrate the potential of PBM as an anti-inflammatory treatment that acts through cytokine expression modulation.

Indexed as

light therapylipopolysaccharide (LPS)neurodegenerative disordersneuroinflammationphotobiomodulation (PBM)systemic inflammation

Identifiers

PMID37090796
PMCPMC10115964
OpenAlexW4362672521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.