Evidence map›Paper›PMID 37090737›Full record

ArticleFrontiers in immunology2023

Chronic alcohol administration alters metabolomic profile of murine bone marrow.

Tássia Tatiane Pontes Pereira, Filipe Fideles Duarte-Andrade, Jéssica Gardone Vitório, Taiane do Espírito Santo Pereira, Flavia Rayssa Braga Martins, Jéssica Amanda Marques Souza, Nathália Luisa Malacco, Eliza Mathias Melo, Carolina Raíssa Costa Picossi, Ernani Pinto and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Tássia Tatiane Pontes PereiraDepartment of Genetics, Ecology and Evolution, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Filipe Fideles Duarte-AndradeDepartment of Clinic, Pathology and Dental Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Jéssica Gardone VitórioDepartment of Clinic, Pathology and Dental Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Taiane do Espírito Santo PereiraDepartment of Analytical Chemistry of the Institute of Chemistry, Universidade Federal da Bahia, Salvador, Brazil.
Flavia Rayssa Braga MartinsDepartment of Genetics, Ecology and Evolution, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Jéssica Amanda Marques SouzaDepartment of Genetics, Ecology and Evolution, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Nathália Luisa MalaccoDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada.
Eliza Mathias MeloDepartment of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Carolina Raíssa Costa PicossiChemistry Institute, University of São Paulo, São Paulo, Brazil.
Ernani PintoNuclear Energy Center in Agriculture, Escola Superior de Agricultura Luiz de Queiroz, University of São Paulo, Piracicaba, Brazil.
Ricardo Santiago GomezDepartment of Clinic, Pathology and Dental Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Mauro Martins TeixeiraDepartment of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Adriana Nori de MacedoChemistry Department, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Gisele André Baptista CanutoDepartment of Analytical Chemistry of the Institute of Chemistry, Universidade Federal da Bahia, Salvador, Brazil.
Frederico Marianetti SorianiDepartment of Genetics, Ecology and Evolution, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Universidade Federal de Minas Gerais · BRUniversidade de São Paulo · BRUniversidade Federal da Bahia · BRMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: People with hazardous alcohol use are more susceptible to viral, bacterial, and fungal infections due to the effect of alcohol on immune system cell function. Metabolized ethanol reduces NAD Methods: We addressed this aim by using C57BL/6 mice under chronic ethanol administration and evaluating the metabolomic profile of bone marrow total cells by gas chromatography-coupled mass spectrometry (GC-MS). Results: We identified 19 metabolites. Our data demonstrated that chronic ethanol administration alters the metabolomic profile in the bone marrow, resulting in a statistically diminished abundance of five metabolites in ethanol-treated animals: uracil, succinate, proline, nicotinamide, and tyrosine. Discussion: Our results demonstrate for the first time in the literature the effects of alcohol consumption on the metabolome content of hematopoietic tissue and open a wide range of further studies to investigate mechanisms by which alcohol compromises the cellular function of the immune system.

Indexed as

Bone MarrowEthanolAnimalsMetabolomeMetabolomicsMiceMice, Inbred C57BLEthanolalcoholismbone marrowcell functionimmune systemmetabolitesmetabolome

Identifiers

PMID37090737
PMCPMC10113543
OpenAlexW4362636670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.