Evidence map›Paper›PMID 37090676›Full record

ArticlebioRxiv : the preprint server for biology2023

Sex biased human thymic architecture guides T cell development through spatially defined niches.

Laura N Stankiewicz, Kevin Salim, Emily A Flaschner, Yu Xin Wang, John M Edgar, Bruce Zb Lin, Grace C Bingham, Matthew C Major, Ross D Jones, Helen M Blau and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Laura N StankiewiczSchool of Biomedical Engineering, University of British Columbia, Canada.
Kevin SalimDepartment of Surgery, University of British Columbia, Canada.
Emily A FlaschnerSchool of Biomedical Engineering, University of British Columbia, Canada.
Yu Xin WangCenter for Genetic Disorders and Aging, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
John M EdgarSchool of Biomedical Engineering, University of British Columbia, Canada.
Bruce Zb LinSchool of Biomedical Engineering, University of British Columbia, Canada.
Grace C BinghamDepartment of Biomedical Engineering, University of Virginia, USA.
Matthew C MajorSchool of Biomedical Engineering, University of British Columbia, Canada.
Ross D JonesSchool of Biomedical Engineering, University of British Columbia, Canada.
Helen M BlauBaxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, USA.
Elizabeth J RideoutLife Sciences Institute, University of British Columbia, Canada.
Megan K LevingsSchool of Biomedical Engineering, University of British Columbia, Canada.
Peter W ZandstraSchool of Biomedical Engineering, University of British Columbia, Canada.
Fabio Mv RossiSchool of Biomedical Engineering, University of British Columbia, Canada.

Funding

Control of Muscle Stem Cells to Enhance RegenerationR01AG075436 · NIA · STANFORD UNIVERSITY · PI Helen M Blau · 2022 to 2026
$2.5M
Regulation of eicosanoid signaling lipids to improve skeletal muscle function and increase healthspan during agingR01AG069858 · NIA · STANFORD UNIVERSITY · PI BLAU, HELEN M · 2020 to 2023
$2.4M
Spatial Regulators of Skeletal Muscle Regeneration and DiseaseR00NS120278 · NINDS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI WANG, YU XIN · 2023 to 2025
$739k
Spatial Regulators of Skeletal Muscle Regeneration and DiseaseK99NS120278 · NINDS · STANFORD UNIVERSITY · PI WANG, YU XIN · 2020 to 2021
$177k
NIA NIH HHS R01 AG069858NIA NIH HHS R01 AG075436NINDS NIH HHS K99 NS120278NINDS NIH HHS R00 NS120278Wellcome Trust
6 · The paper itself

Abstract

Within the thymus, regulation of the cellular cross-talk directing T cell development is dependent on spatial interactions within specialized niches. To create a holistic, spatially defined map of tissue niches guiding postnatal T cell development we employed the multidimensional imaging platform CO-detection by indEXing (CODEX), as well as CITE-seq and ATAC-seq. We generated age-matched 4-5-month-old postnatal thymus datasets for male and female donors, and identify significant sex differences in both T cell and thymus biology. We demonstrate a crucial role for JAG ligands in directing thymic-like dendritic cell development, reveal important functions of a novel population of ECM

Identifiers

PMID37090676
PMCPMC10120731

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.