ArticleResearch square2023
The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts.
In Young Choi, Jonathan Ling, Jian Zhang, Eric Helmenstine, Wencke Walter, Riley Bergman, Céline Philippe, James Manley, Kevin Rouault-Pierre, Bing Li and 10 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
20 authors at 11 institutions in 4 countries.
In Young ChoiJohns Hopkins University School of Medicine.
Jonathan LingJohns Hopkins University.
Eric HelmenstineJohns Hopkins University.
Riley BergmanVanderbilt University.
James ManleyColumbia University.
Bing LiInstitute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.
Madhu OusephWeill Cornell Medical College.
Xiao LiShanghai Jiao Tong University Affiliated Sixth People's Hospital.
Torsten HaferlachMLL Munich Leukemia Laboratory.
Salman FazalAllegheny Health Network.
W Brian DaltonJohns Hopkins Medicine.
Johns Hopkins University · USColumbia University · USMunich Leukemia Laboratory (Germany) · DEQueen Mary University of London · GBAllegheny Health Network · USChinese Academy of Medical Sciences & Peking Union Medical College · CNCornell University · USMemorial Sloan Kettering Cancer Center · USShanghai Jiao Tong University · CNUniversity of Manchester · GBVanderbilt University Medical Center · US
Funding
Regulation of RNA processing: Mechanisms and ConsequencesR35GM118136 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI James L. Manley · 2016 to 2026
$8.9MBiologic and Therapeutic Consequences of Distinct Hotspot SF3B1 Mutations in MDSR01HL159306 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI DALTON, WILLIAM BRIAN, DEZERN, AMY E · 2022 to 2025
$1.6MBiologic and Therapeutic Consequences of Distinct Hotspot SF3B1 Mutations in MDSR56HL159306 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI DALTON, WILLIAM BRIAN, DEZERN, AMY E · 2021 to 2021
$409kHarnessing hotspot specific differences among SF3B1 mutations to define novel mechanisms of tumorigenicity and targetability in solid malignanciesF30CA268325 · NCI · VANDERBILT UNIVERSITY · PI BERGMAN, RILEY · 2023 to 2025
$141kNCI NIH HHS F30 CA268325NHLBI NIH HHS R01 HL159306NHLBI NIH HHS R56 HL159306NIGMS NIH HHS R35 GM118136
6 · The paper itselfAbstract
Among the most common genetic alterations in the myelodysplastic syndromes (MDS) are mutations in the spliceosome gene
Identifiers
PMID37090662
PMCPMC10120771
OpenAlexW4365509745
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