Evidence map›Paper›PMID 37090661›Full record

ArticleResearch square2023

Enantio- and Diastereoenriched Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes from (Z/E)-Trisubstituted Enol Acetates.

Runze Mao, Daniel J Wackelin, Cooper S Jamieson, Torben Rogge, Shilong Gao, Anuvab Das, Doris Mia Taylor, K N Houk, Frances H Arnold

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Runze MaoDivision of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, California, 91125, United States.ORCID 0000-0002-7361-560X
Daniel J WackelinDivision of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, California, 91125, United States.
Cooper S JamiesonDivision of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, California, 91125, United States.
Torben RoggeDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.
Shilong GaoDivision of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, California, 91125, United States.
Anuvab DasDivision of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, California, 91125, United States.
Doris Mia TaylorDivision of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, California, 91125, United States.
K N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.
Frances H ArnoldDivision of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, California, 91125, United States.ORCID 0000-0002-4027-364X
California Institute of Technology · USUniversity of California, Los Angeles · US

Funding

Breakthrough Molecular Dynamics Research via an Anton2 SupercomputerR01GM116961 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D. · 2016 to 2023
$3.0M
Biocatalytic C–H Functionalization Forms Nitrogen HeterocyclesF32GM145009 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI JAMIESON, COOPER STERGIS · 2022 to 2022
$52k
NIGMS NIH HHS F32 GM145009
6 · The paper itself

Abstract

In nature and synthetic chemistry, stereoselective [2+1] cyclopropanation is the most prevalent strategy for the synthesis of chiral cyclopropanes, a class of key pharmacophores in pharmaceuticals and bioactive natural products. One of the most extensively studied reactions in the organic chemist's arsenal, stereoselective [2+1] cyclopropanation, largely relies on the use of stereodefined olefins, which require elaborate laboratory synthesis or tedious separation to ensure high stereoselectivity. Here we report engineered hemoproteins derived from a bacterial cytochrome P450 that catalyze the synthesis of chiral 1,2,3-polysubstituted cyclopropanes, regardless of the stereopurity of the olefin substrates used. Cytochrome P450

Identifiers

PMID37090661
PMCPMC10120758
OpenAlexW4364374972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.