Evidence map›Paper›PMID 37090634›Full record

ArticleResearch square2023

Sclerostin antibody improves alveolar bone quality in the

Ryan Ross, Kelsey Carpenter, Delia Alkhatib, Bryan Dulion, Elizabeth Guirado, Shreya Patel, Yinghua Chen, Anne George

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ryan RossRush University Medical Center.ORCID 0000-0003-3760-234X
Kelsey CarpenterRush University Medical Center.
Delia AlkhatibRush University Medical Center.
Bryan DulionRush University Medical Center.
Elizabeth GuiradoUIC.
Shreya PatelRush University Medical Center.
Yinghua ChenUniversity of Illinois Chicago College of Dentistry.
Anne GeorgeDepartment of Oral Biology.
Rush University Medical Center · USUniversity of Illinois Chicago · US

Funding

Role of DMP1 Mediated Paracrine Signaling in VasculogenesisR01DE031737 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Anne George · 2022 to 2026
$2.5M
Sclerostin Regulation of Skeletal Mineralization and Phosphate MetabolismK01AR073923 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI ROSS, RYAN DEE · 2019 to 2022
$462k
Assessing the function role of sclerostin in periodontal disease in XLHR03DE029873 · NIDCR · RUSH UNIVERSITY MEDICAL CENTER · PI ROSS, RYAN DEE · 2021 to 2022
$329k
NIAMS NIH HHS K01 AR073923NIDCR NIH HHS R01 DE031737NIDCR NIH HHS R03 DE029873
6 · The paper itself

Abstract

X-linked hypophosphatemia (XLH) is a rare disease of elevated fibroblast growth factor 23 (FGF23) production that leads to hypophosphatemia and poor mineralization of bone and teeth. The clinical manifestations of XLH include a high prevalence of dental abscesses, likely driven by poorly formed structures of the dentoalveolar complex, including the alveolar bone, cementum, dentin, and periodontal ligament. Our previous studies have demonstrated that sclerostin antibody (Scl-Ab) treatment improves phosphate homeostasis, and increases bone mass, strength and mineralization in the

Indexed as

hypophosphatemiamineralized tissue/developmentosteomalaciaperiodontiumRickets

Identifiers

PMID37090634
PMCPMC10120757
OpenAlexW4365138594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.