Evidence map›Paper›PMID 37090621›Full record

ArticleResearch square2023

Tumor-restrictive type III collagen in the breast cancer microenvironment: prognostic and therapeutic implications.

Becky K Brisson, Bassil Dekky, Ashton C Berger, Elizabeth A Mauldin, Claudia Loebel, William Yen, Daniel C Stewart, Deborah Gillette, Charles-Antoine Assenmacher, Edna Cukierman and 3 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Becky K BrissonDepartment of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Bassil DekkyDepartment of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ashton C BergerDepartment of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Elizabeth A MauldinDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Claudia LoebelDepartment of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
William YenDepartment of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Daniel C StewartDepartment of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Deborah GilletteDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Charles-Antoine AssenmacherDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Edna CukiermanCancer Signaling and Microenvironment Program, The Martin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.
Jason A BurdickDepartment of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Virginia F BorgesDepartment of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Susan W VolkDepartment of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-3993-4145
University of Pennsylvania · USBroad Institute · USFox Chase Cancer Center · USUniversity of Colorado Boulder · USUniversity of Colorado Cancer Center · USUniversity of Michigan · US

Funding

Pancreatic Cancer-Associated Fibroblasts: Function, Detection, and RegulationR01CA269660 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Edna Cukierman · 2022 to 2026
$3.1M
Short-term Training: students in health professional schoolsT35OD010919 · OD · UNIVERSITY OF PENNSYLVANIA · PI Michael Lee Atchison · 2012 to 2026
$1.8M
Building Enhanced Capability for the PennVet Multiphoton CoreS10OD021633 · OD · UNIVERSITY OF PENNSYLVANIA · PI FREEDMAN, BRUCE D · 2016 to 2016
$600k
Multiphoton microscopy systemS10OD023666 · OD · RESEARCH INST OF FOX CHASE CAN CTR · PI YEN, TIMOTHY · 2018 to 2018
$600k
FLIM system, resonant scanner, and UV laser for 2 photon microscopeS10RR027128 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FREEDMAN, BRUCE D · 2010 to 2010
$496k
Type III Collagen as a suppressor of breast cancer progression and metastasisR21CA216552 · NCI · UNIVERSITY OF PENNSYLVANIA · PI VOLK, SUSAN W · 2018 to 2019
$379k
Aperio VERSA Digital Slide Scanner, eSlide Manager Database, and Advanced Image Analysis SoftwareS10OD023465 · OD · UNIVERSITY OF PENNSYLVANIA · PI DURHAM, AMY CLEVELAND · 2018 to 2018
$329k
NCI NIH HHS R01 CA269660NCI NIH HHS R21 CA216552NCRR NIH HHS S10 RR027128NIH HHS S10 OD021633NIH HHS S10 OD023465NIH HHS S10 OD023666NIH HHS T35 OD010919
6 · The paper itself

Abstract

Collagen plays a critical role in regulating breast cancer progression and therapeutic resistance. An improved understanding of both the features and drivers of tumor-permissive and -restrictive collagen matrices are critical to improve prognostication and develop more effective therapeutic strategies. In this study, using a combination of

Indexed as

BRCAbreast cancercollagenmammary tumorsmetastasisTNBCtumor microenvironmenttumor stromatype III collagen

Identifiers

PMID37090621
PMCPMC10120781
OpenAlexW4365148247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.