Evidence map›Paper›PMID 37090616›Full record

ArticlebioRxiv : the preprint server for biology2023

The contributions of DNA accessibility and transcription factor occupancy to enhancer activity during cellular differentiation.

Trevor Long, Tapas Bhattacharyya, Andrea Repele, Madison Naylor, Sunil Nooti, Shawn Krueger, Manu

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Trevor LongDepartment of Biology, University of North Dakota, Grand Forks, 58202-9019 ND, USA.
Tapas BhattacharyyaDepartment of Biology, University of North Dakota, Grand Forks, 58202-9019 ND, USA.
Andrea RepeleDepartment of Biology, University of North Dakota, Grand Forks, 58202-9019 ND, USA.
Madison NaylorDepartment of Biology, University of North Dakota, Grand Forks, 58202-9019 ND, USA.
Sunil NootiDepartment of Biology, University of North Dakota, Grand Forks, 58202-9019 ND, USA.
Shawn KruegerDepartment of Biology, University of North Dakota, Grand Forks, 58202-9019 ND, USA.
ManuDepartment of Biology, University of North Dakota, Grand Forks, 58202-9019 ND, USA.
University of North Dakota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The upregulation of gene expression by enhancers depends upon the interplay between the binding of sequence-specific transcription factors (TFs) and DNA accessibility. DNA accessibility is thought to limit the ability of TFs to bind to their sites, while TFs can increase accessibility to recruit additional factors that upregulate gene expression. Given this interplay, the causative regulatory events underlying the modulation of gene expression during cellular differentiation remain unknown for the vast majority of genes. We investigated the binding-site resolution dynamics of DNA accessibility and the expression dynamics of the enhancers of an important neutrophil gene,

Identifiers

PMID37090616
PMCPMC10120690
OpenAlexW4321607231

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.