Evidence map›Paper›PMID 37090609›Full record

ArticlebioRxiv : the preprint server for biology2024

Rbm8a deficiency causes hematopoietic defects by modulating Wnt/PCP signaling.

Agnese Kocere, Elena Chiavacci, Charlotte Soneson, Harrison H Wells, Kevin Manuel Méndez-Acevedo, Jacalyn S MacGowan, Seth T Jacobson, Max S Hiltabidle, Azhwar Raghunath, Jordan A Shavit and 5 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Agnese KocereDepartment of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-3442-5731
Elena ChiavacciDepartment of Molecular Life Sciences, University of Zürich, Zürich, Switzerland.ORCID 0000-0003-3924-3635
Charlotte SonesonDepartment of Molecular Life Sciences, University of Zürich, Zürich, Switzerland.ORCID 0000-0003-3833-2169
Harrison H WellsDepartment of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-2294-2352
Kevin Manuel Méndez-AcevedoMax Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association, Berlin-Buch, Germany.ORCID 0000-0001-9872-7192
Jacalyn S MacGowanCenter for Precision Environmental Health and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Seth T JacobsonDepartment of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Max S HiltabidleDepartment of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-5806-1485
Azhwar RaghunathDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0001-5217-0341
Jordan A ShavitDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-2874-4904
Daniela PanákováMax Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association, Berlin-Buch, Germany.ORCID 0000-0002-8739-6225
Margot L K WilliamsCenter for Precision Environmental Health and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-9704-6301
Mark D RobinsonDepartment of Molecular Life Sciences, University of Zürich, Zürich, Switzerland.ORCID 0000-0002-3048-5518
Christian MosimannDepartment of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-0749-2576
Alexa BurgerDepartment of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-7137-3910
University of Colorado Anschutz Medical Campus · USBaylor College of Medicine · USMax Delbrück Center · DESIB Swiss Institute of Bioinformatics · CHUniversity of Michigan · USUniversity of Zurich · CH

Funding

Genetic and therapeutic studies of hemostatic and thrombotic disorders using zebrafishR35HL150784 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jordan A. Shavit · 2020 to 2026
$5.4M
Predoctoral Training in the Genetics of Development, Disease and RegenerationT32GM141742 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Bruce H Appel, Jeffrey Kyle Moore · 2021 to 2026
$1.9M
Developmental causes of syndromic Thrombocytopenia and co-morbiditiesR01DK129350 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BURGER, ALEXA · 2022 to 2024
$690k
Defining Direct and Indirect Roles of Nodal Signaling in Convergence & ExtensionR00HD091386 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI WILLIAMS, MARGOT L.K. · 2020 to 2022
$680k
NHLBI NIH HHS R35 HL150784NICHD NIH HHS R00 HD091386NIDDK NIH HHS R01 DK129350NIGMS NIH HHS T32 GM141742
6 · The paper itself

Abstract

Defects in blood development frequently occur among syndromic congenital anomalies. Thrombocytopenia-Absent Radius (TAR) syndrome is a rare congenital condition with reduced platelets (hypomegakaryocytic thrombocytopenia) and forelimb anomalies, concurrent with more variable heart and kidney defects. TAR syndrome associates with hypomorphic gene function for

Indexed as

developmenthematopoiesismorphogenesisnon-canonical Wntthrombocytopeniazebrafish

Identifiers

PMID37090609
PMCPMC10120739
OpenAlexW4365137575

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.