Evidence map›Paper›PMID 37090596›Full record

ArticleResearch square2023

Danish Population Based Study of Familial Epilepsy and Childhood Cancer.

Corbin Platamone, Xiwen Huang, Rajarshi Mazumder, Beate Ritz, Jorn Olsen, Johnni Hansen, Chai Saechao, Julia E Heck

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Corbin PlatamoneUCLA School of Public Health: University of California Los Angeles Jonathan and Karin Fielding School of Public Health.ORCID 0000-0002-7968-5166
Xiwen HuangUCLA School of Public Health: University of California Los Angeles Jonathan and Karin Fielding School of Public Health.
Rajarshi MazumderDavid Geffen School of Medicine: University of California Los Angeles David Geffen School of Medicine.
Beate RitzUCLA School of Public Health: University of California Los Angeles Jonathan and Karin Fielding School of Public Health.
Jorn OlsenAarhus University Department of Clinical Medicine: Aarhus Universitet Institut for Klinisk Medicin.
Johnni HansenDanish Cancer Society: Kraeftens Bekaempelse.
Chai SaechaoUCLA Health System: University of California Los Angeles Health System.
Julia E HeckUCLA School of Public Health: University of California Los Angeles Jonathan and Karin Fielding School of Public Health.
University of California, Los Angeles · USAarhus University · DKDanish Cancer Society · DK

Funding

Maternal comorbidities, prescription drug use in pregnancy and childhood cancerR21CA175959 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2014 to 2015
$323k
Parental Occupation and Childhood CancersR03ES021643 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2012 to 2013
$152k
NCI NIH HHS R21 CA175959NIEHS NIH HHS R03 ES021643
6 · The paper itself

Abstract

Objective: Results from studies investigating the association between maternal or child epilepsy, use of anticonvulsants in pregnancy, and childhood cancer are inconsistent and at times contradictory. Methods: Linking Danish national databases, we obtained epilepsy and childhood cancer diagnoses, and anticonvulsant use data. We estimated adjusted odds ratios of all or specific childhood cancers in relation to maternal or child epilepsy and anticonvulsant therapies using conditional logistic regression. Results: Maternal epilepsy was positively associated with all childhood cancers in offspring, specifically, with acute lymphoblastic leukemia (Odds Ratio (OR) = 1.68, 95% Confidence Interval (CI) = 1.16, 2.43) and Wilms tumor (OR = 2.13, 95%CI = 0.97, 4.68). When considering maternal ever (lifetime) ingestion of anticonvulsants, a positive association was found with all cancers (OR = 1.15, 95%CI = 1.01, 1.31), and central nervous system tumors (OR = 1.32, 95%CI = 1.03, 1.69) as well as neuroblastoma (OR = 2.05, 95%CI = 1.29, 3.28) among offspring. Maternal anticonvulsant use before or during the index pregnancy was related to CNS tumors in offspring (OR = 1.78, 95%CI = 0.99, 3.21), however the confidence interval included the null. Significance: Maternal use of certain anticonvulsant medications may be a risk factor for cancer in offspring. Medical providers may need to consider what type of treatments to prescribe to pregnant mothers with epilepsy.

Indexed as

Antiepileptic medicationsChildhood cancerDanish population based studyIn-utero exposureMaternal Epilepsy

Identifiers

PMID37090596
PMCPMC10120770
OpenAlexW4365513149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.