Evidence map›Paper›PMID 37090552›Full record

ArticlebioRxiv : the preprint server for biology2023

Brianne B Rogers, Ashlyn G Anderson, Shelby N Lauzon, M Natalie Davis, Rebecca M Hauser, Sydney C Roberts, Ivan Rodriguez-Nunez, Katie Trausch-Lowther, Erin A Barinaga, Jared W Taylor and 6 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Brianne B RogersHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Ashlyn G AndersonHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Shelby N LauzonHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
M Natalie DavisHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Rebecca M HauserHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Sydney C RobertsHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Ivan Rodriguez-NunezHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Katie Trausch-LowtherHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Erin A BarinagaHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Jared W TaylorHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Mark MackiewiczHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Brian S RobertsHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Sara J CooperHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Lindsay F RizzardiHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Richard M MyersHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
J Nicholas CochranHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
HudsonAlpha Institute for Biotechnology · USUniversity of Alabama at Birmingham · US

Funding

UAB Research Training Program in Neurobiology of Cognition and Cognitive DisordersT32NS061788 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Farah Dominique Lubin · 2008 to 2026
$4.5M
UAB Neuroscience Roadmap Scholars ProgramR25NS089463 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LUBIN, FARAH DOMINIQUE · 2014 to 2024
$2.7M
Regulatory mechanisms of rare non-coding variation in neurodegeneration-associated lociR00AG068271 · NIA · HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY · PI COCHRAN, JESSE N · 2021 to 2023
$725k
Regulatory mechanisms of rare non-coding variation in neurodegeneration-associated lociK99AG068271 · NIA · HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY · PI COCHRAN, JESSE N · 2020 to 2020
$118k
Austrian Science Fund FWF I 904NIA NIH HHS K99 AG068271NIA NIH HHS R00 AG068271NINDS NIH HHS R25 NS089463NINDS NIH HHS T32 NS061788
6 · The paper itself

Abstract

Background: Tauopathies are a group of neurodegenerative diseases driven by abnormal aggregates of tau, a microtubule associated protein encoded by the Methods: We performed HiC, chromatin conformation capture (Capture-C), single-nucleus multiomics (RNA-seq+ATAC-seq), bulk ATAC-seq, and ChIP-seq for H3K27Ac and CTCF in NPCs and neurons differentiated from human iPSC cultures. We nominated candidate cis-regulatory elements (cCREs) for Results: Using orthogonal genomics approaches, we nominated 94 cCREs for Conclusions: We identified both proximal and distal regulatory elements for

Indexed as

Alzheimer’s diseaseEnhancerGene regulationMAPTNeuron

Identifiers

PMID37090552
PMCPMC10120716
OpenAlexW4323544257

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.