Evidence map›Paper›PMID 37090547›Full record

ArticlebioRxiv : the preprint server for biology2023

Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors.

Zebin Xiao, Leslie Todd, Li Huang, Estela Noguera-Ortega, Zhen Lu, Lili Huang, Meghan Kopp, Yue Li, Nimisha Pattada, Wenqun Zhong and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 12 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Zebin XiaoDepartment of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Leslie ToddDepartment of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Li HuangDepartment of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Estela Noguera-OrtegaDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Zhen LuDepartment of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lili HuangDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Meghan KoppDepartment of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yue LiDepartment of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nimisha PattadaDepartment of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wenqun ZhongDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wei GuoDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
John SchollerCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Maria LiousiaDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Charles-Antoine AssenmacherDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Carl H JuneCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Steven M AlbeldaDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ellen PuréDepartment of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
University of Pennsylvania · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 1985 to 2026
$222.3M
TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 1997 to 2026
$32.5M
Project 3 - Immune analysis of clinical trial samplesP01CA217805 · NCI · UNIVERSITY OF PENNSYLVANIA · PI HWANG, WEI-TING · 2018 to 2022
$10.4M
NCI NIH HHS P01 CA217805NCI NIH HHS P30 CA016520NIDDK NIH HHS P30 DK050306
6 · The paper itself

Abstract

The desmoplastic stroma in solid tumors presents a formidable challenge to immunotherapies that rely on endogenous or adoptively transferred T cells, however, the mechanisms are poorly understood. To define mechanisms involved, we treat established desmoplastic pancreatic tumors with CAR T cells directed to fibroblast activation protein (FAP), an enzyme highly overexpressed on a subset of cancer-associated fibroblasts (CAFs). Depletion of FAP

Identifiers

PMID37090547
PMCPMC10120701
OpenAlexW4366003069

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.