Evidence map›Paper›PMID 37090534›Full record

ArticlebioRxiv : the preprint server for biology2023

Cryo-EM structure of the human cardiac myosin filament.

Debabrata Dutta, Vu Nguyen, Kenneth S Campbell, Raúl Padrón, Roger Craig

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 18 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

University of Massachusetts Chan Medical School · USUniversity of Kentucky · US

Funding

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Dual filament control of myocardial power and hemodynamicsR01HL148785 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Kenneth S Campbell, Thomas Kampourakis · 2020 to 2026
$3.2M
Structural basis of the super-relaxed state in human cardiac muscleR01HL164560 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI PADRON, RAUL · 2022 to 2025
$2.8M
Length-dependent activation in human myocardiumR01HL149164 · NHLBI · UNIVERSITY OF KENTUCKY · PI CAMPBELL, KENNETH S, TANNER, BERTRAND C.W. · 2020 to 2023
$2.8M
Mechanism of regulation of cardiac contraction by phosphorylation of myosin binding protein CR01HL139883 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI CRAIG, ROGER W, RALPHE, JOHN CARTER · 2018 to 2021
$2.7M
Dissecting the structural origin of relaxation in skeletal muscleR01AR081941 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Raul Padron · 2023 to 2026
$2.2M
Structure of The Interacting-Heads Motif in Myosin Filaments and MoleculesR01AR072036 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CRAIG, ROGER W · 2017 to 2021
$2.1M
Murine 3D Engineered Tissue Model of Human MYBPC3 MutationsR01HL107367 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI RALPHE, JOHN CARTER · 2011 to 2015
$1.8M
NHLBI NIH HHS R01 HL107367NHLBI NIH HHS R01 HL139883NHLBI NIH HHS R01 HL148785NHLBI NIH HHS R01 HL164560NIAMS NIH HHS R01 AR072036NIAMS NIH HHS R01 AR081941
6 · The paper itself

Abstract

Pumping of the heart is powered by filaments of the motor protein myosin, which pull on actin filaments to generate cardiac contraction. In addition to myosin, the filaments contain cardiac myosin-binding protein C (cMyBP-C), which modulates contractility in response to physiological stimuli, and titin, which functions as a scaffold for filament assembly

Identifiers

PMID37090534
PMCPMC10120621
OpenAlexW4365138634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.