Evidence map›Paper›PMID 37090508›Full record

ArticlebioRxiv : the preprint server for biology2025

Deletion of Neuroligins from Astrocytes Does Not Detectably Alter Synapse Numbers or Astrocyte Cytoarchitecture by Maturity.

Samantha R Golf, Justin H Trotter, Jinzhao Wang, George Nakahara, Xiao Han, Marius Wernig, Thomas C Südhof

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Samantha R GolfDept. of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-9881-084X
Justin H TrotterDept. of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jinzhao WangDept. of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
George NakaharaDept. of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Xiao HanDept. of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Marius WernigDepartment of Pathology, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA.
Thomas C SüdhofDept. of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stanford University · USHoward Hughes Medical Institute · USUniversity of Alabama at Birmingham · USUniversity of California San Diego · US

Funding

Training Program in Basic NeuroscienceT32MH020016 · NIMH · STANFORD UNIVERSITY · PI Justin L Gardner, Merritt C Maduke · 1997 to 2026
$16.2M
Induced neuronal cells: A novel tool to study neuropsychiatric diseasesR01MH092931 · NIMH · STANFORD UNIVERSITY · PI Thomas C. Sudhof, Marius Wernig · 2010 to 2026
$9.7M
Molecular Logic Sculpting Cell-Specific Contributions of Neurexin-1 at the Tripartite SynapseK01MH123788 · NIMH · STANFORD UNIVERSITY · PI TROTTER, JUSTIN HOWARD · 2021 to 2023
$455k
NIMH NIH HHS K01 MH123788NIMH NIH HHS R01 MH092931NIMH NIH HHS T32 MH020016
6 · The paper itself

Abstract

Astrocytes perform multifarious roles in the formation, regulation, and function of synapses in the brain, but the mechanisms involved are incompletely understood. Interestingly, astrocytes abundantly express neuroligins, postsynaptic adhesion molecules that function as synaptic organizers by binding to presynaptic neurexins. Here we examined the function of neuroligins in astrocytes with a rigorous genetic approach that uses the conditional deletion of all major neuroligins (

Identifiers

PMID37090508
PMCPMC10120619
OpenAlexW4365150363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.