Evidence map›Paper›PMID 37089824›Full record

ArticleMetabolism open2023

Comparative assessment of hepatoprotective properties of Artesunate and flavonoids from

Marie Ange Djeungoue Petga, Arnaud Fondjo Kouam, Rosine Désirée Chougouo Kengne, Boris Rosnay Galani Tietcheu, Josué Simo Louokdom, Claude Bérenger Ngantchouko Ngalemo, Pascal Dieudonné Chuisseu Djamen, Paul Fewou Moundipa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolism open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. ACS omega · 2025
    Article
  3. Extracts ofAvicenna journal of phytomedicine
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marie Ange Djeungoue PetgaHigher Institute of Health Sciences, Université des Montagnes, P.O. Box 208, Bangangté, Cameroon.
Arnaud Fondjo KouamMedical Research and Applied Biochemistry Laboratory, Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, PO Box 63, Buea, Cameroon.
Rosine Désirée Chougouo KengneHigher Institute of Health Sciences, Université des Montagnes, P.O. Box 208, Bangangté, Cameroon.
Boris Rosnay Galani TietcheuLaboratory of Pharmacology and Toxicology, Department of Biochemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaounde 1, Cameroon.
Josué Simo LouokdomHigher Institute of Health Sciences, Université des Montagnes, P.O. Box 208, Bangangté, Cameroon.
Claude Bérenger Ngantchouko NgalemoHigher Institute of Health Sciences, Université des Montagnes, P.O. Box 208, Bangangté, Cameroon.
Pascal Dieudonné Chuisseu DjamenHigher Institute of Health Sciences, Université des Montagnes, P.O. Box 208, Bangangté, Cameroon.
Paul Fewou MoundipaLaboratory of Pharmacology and Toxicology, Department of Biochemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaounde 1, Cameroon.
Université des Montagnes · CMUniversité de Yaoundé I · CM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Artesunate (ART) is a semi-synthetized molecule from Artemisinin, an active compound isolated from the medicinal plant Methods: The antioxidant activities of FAA and Ascorbic acid (ASC) (0.01-100 μg/mL) were assessed through inhibition of lipid peroxidation, reduction of ferric and phosphomolydenum, and hydroxyl and DPPH radicals scavenging assays. The hepatoprotective effects of FAA and ART (0.1-100 μg/mL) were evaluated against APAP (11 mM) or CCl4 (4 mM) induced oxidative damage in primary mouse hepatocytes. Biochemical parameters associated with hepatotoxicity assessed include cell viability, cell membrane integrity, cellular glutathione, and antioxidant enzyme activities. Results: The obtained finding revealed FAA displayed a remarkable antioxidant activities as evidenced by the low IC Conclusion: Overall, our data demonstrated that ART harms mice hepatocytes at high concentration while conferring relative protection against APAP and CCl

Indexed as

AcetaminophenAntioxidant activitiesArtesunateCarbon tetrachlorideFlavonoid from Artemesia annuaHepatotoxicity

Identifiers

PMID37089824
PMCPMC10114220
OpenAlexW4362663386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.