Evidence map›Paper›PMID 37089813›Full record

ArticleNAR cancer2023

Deletion of the mRNA stability factor

Grace A McCarthy, Roberto Di Niro, Jennifer M Finan, Aditi Jain, Yifei Guo, Cory R Wyatt, Alexander R Guimaraes, Trent A Waugh, Dove Keith, Terry K Morgan and 2 more

Open access · goldAbstract read
In one paragraph

Article in NAR cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Embryonic Lethal Abnormal Visual-Like Protein 1 Aggravates Caerulein-Induced AR42J Cell Injury and Macrophage M1 Polarization to Accelerate Acute Pancreatitis by Upregulating TRAF6.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2025
    Article
  8. mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  9. Review
  10. HuR controls glutaminase RNA metabolism.Nature communications · 2024
    Article
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Grace A McCarthyDepartment of Surgery, Oregon Health & Science University, Portland, OR 97239, USA.ORCID https://orcid.org/0000-0002-6628-2755
Roberto Di NiroDepartment of Surgery, Oregon Health & Science University, Portland, OR 97239, USA.
Jennifer M FinanDepartment of Surgery, Oregon Health & Science University, Portland, OR 97239, USA.ORCID https://orcid.org/0000-0001-7706-1643
Aditi JainThe Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID https://orcid.org/0000-0001-9383-7501
Yifei GuoDepartment of Surgery, Oregon Health & Science University, Portland, OR 97239, USA.
Cory R WyattDepartment of Diagnostic Radiology, Oregon Health & Science University, Portland, OR 97239, USA.
Alexander R GuimaraesKnight Cancer Institute, Oregon Health & Science University, Portland, OR 97201, USA.
Trent A WaughBrenden-Colson Center for Pancreatic Care, Oregon Health & Science University, Portland, OR 97201, USA.
Dove KeithBrenden-Colson Center for Pancreatic Care, Oregon Health & Science University, Portland, OR 97201, USA.
Terry K MorganDepartment of Pathology, Oregon Health & Science University, Portland, OR 97239, USA.
Rosalie C SearsBrenden-Colson Center for Pancreatic Care, Oregon Health & Science University, Portland, OR 97201, USA.
Jonathan R BrodyDepartment of Surgery, Oregon Health & Science University, Portland, OR 97239, USA.
Oregon Health & Science University · USThomas Jefferson University · US

Funding

Comparative analysis between patient-derived models of pancreatic ductal adenocarcinomas and matched tumor specimensU01CA224012 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BRODY, JONATHAN, COUSSENS, LISA M. · 2019 to 2023
$2.9M
Targeting HuR to improve a synthetic lethal therapy for pancreatic cancerR01CA212600 · NCI · THOMAS JEFFERSON UNIVERSITY · PI BRODY, JONATHAN · 2017 to 2021
$1.9M
Developing a patient derived model platform to treat BRCA1/2-mutant pancreatic cancersR21CA263996 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BRODY, JONATHAN, SEARS, ROSALIE C · 2022 to 2023
$370k
NCI NIH HHS R01 CA212600NCI NIH HHS R21 CA263996NCI NIH HHS U01 CA224012
6 · The paper itself

Abstract

Stromal cells promote extensive fibrosis in pancreatic ductal adenocarcinoma (PDAC), which is associated with poor prognosis and therapeutic resistance. We report here for the first time that loss of the RNA-binding protein human antigen R (HuR,

Identifiers

PMID37089813
PMCPMC10113877
OpenAlexW4366423651

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.