Evidence map›Paper›PMID 37089775›Full record

ArticleOpen forum infectious diseases2023

Successful Treatment of Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Patients With Immunodeficiency With Extended Nirmatrelvir/Ritonavir: Case Series.

Madison Breeden, Samuel L Aitken, Ji Hoon Baang, Misty Gravelin, Daniel R Kaul, Adam S Lauring, Lindsay A Petty, Kevin S Gregg

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Protracted SARS-CoV-2 Infection in B-cell Depleted Patients: Immunologic and Viral Characteristics and Response to Dual and Extended Antiviral Therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  2. Current infectious disease management challenges in inborn errors of immunity.Annals of clinical microbiology and antimicrobials · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Madison BreedenDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0003-2368-740X
Samuel L AitkenDepartment of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.
Ji Hoon BaangDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Misty GravelinMichigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, Michigan, USA.
Daniel R KaulDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Adam S LauringDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0003-2906-8335
Lindsay A PettyDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Kevin S GreggDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Funding

TEAMSS – Transforming Expanded Access to Maximize Support & StudyU01TR002488 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER, WEATHERWAX, KEVIN J · 2018 to 2022
$4.8M
NCATS NIH HHS U01 TR002488
6 · The paper itself

Abstract

Immunocompromised patients with B-cell deficiencies are at risk for prolonged symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We describe 4 patients treated for B-cell malignancies with B-cell-depleting therapies who developed persistent SARS-CoV-2 infection and had resolution of symptoms following an extended course of nirmatrelvir/ritonavir.

Indexed as

immunodeficiencyprolonged infectionSARS-CoV-2

Identifiers

PMID37089775
PMCPMC10114524

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.