Evidence map›Paper›PMID 37089470›Full record

ArticlePattern recognition2022

Deep learning of longitudinal mammogram examinations for breast cancer risk prediction.

Saba Dadsetan, Dooman Arefan, Wendie A Berg, Margarita L Zuley, Jules H Sumkin, Shandong Wu

Open access · greenAbstract read
In one paragraph

Article in Pattern recognition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  7. Article
  8. Review
  9. Proceedings of the ... AAAI Conference on Artificial Intelligence. AAAI Conference on Artificial Intelligence · 2026
    Article
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  13. Review
  14. Deep learning algorithm on H&E whole slide images to characterizeComputational and structural biotechnology journal · 2024
    Article
  15. On the bias in the AUC variance estimate.Pattern recognition letters · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Saba DadsetanIntelligent Systems Program, School of Computing and Information, University of Pittsburgh, 210 S Bouquet St, Pittsburgh, PA 15213, USA.
Dooman ArefanDepartment of Radiology, University of Pittsburgh School of Medicine, 4200 Fifth Ave, Pittsburgh, PA 15260, USA.
Wendie A BergDepartment of Radiology, University of Pittsburgh School of Medicine, 4200 Fifth Ave, Pittsburgh, PA 15260, USA.
Margarita L ZuleyDepartment of Radiology, University of Pittsburgh School of Medicine, 4200 Fifth Ave, Pittsburgh, PA 15260, USA.
Jules H SumkinDepartment of Radiology, University of Pittsburgh School of Medicine, 4200 Fifth Ave, Pittsburgh, PA 15260, USA.
Shandong WuIntelligent Systems Program, School of Computing and Information, University of Pittsburgh, 210 S Bouquet St, Pittsburgh, PA 15213, USA.
University of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
Quantitative assessment of breast MRIs for breast cancer risk predictionR01CA193603 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WU, SHANDONG · 2015 to 2018
$1.7M
SCH: Leverage clinical knowledge to augment deep learning analysis of breast imagesR01EB032896 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WU, SHANDONG · 2021 to 2024
$1.4M
Deep interpretation of mammographic images in breast cancer screeningR01CA218405 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WU, SHANDONG · 2018 to 2021
$1.4M
NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA193603NCI NIH HHS R01 CA218405NIBIB NIH HHS R01 EB032896
6 · The paper itself

Abstract

Information in digital mammogram images has been shown to be associated with the risk of developing breast cancer. Longitudinal breast cancer screening mammogram examinations may carry spatiotemporal information that can enhance breast cancer risk prediction. No deep learning models have been designed to capture such spatiotemporal information over multiple examinations to predict the risk. In this study, we propose a novel deep learning structure, LRP-NET, to capture the spatiotemporal changes of breast tissue over multiple negative/benign screening mammogram examinations to predict near-term breast cancer risk in a case-control setting. Specifically, LRP-NET is designed based on clinical knowledge to capture the imaging changes of bilateral breast tissue over four sequential mammogram examinations. We evaluate our proposed model with two ablation studies and compare it to three models/settings, including 1) a "loose" model without explicitly capturing the spatiotemporal changes over longitudinal examinations, 2) LRP-NET but using a varying number (i.e., 1 and 3) of sequential examinations, and 3) a previous model that uses only a single mammogram examination. On a case-control cohort of 200 patients, each with four examinations, our experiments on a total of 3200 images show that the LRP-NET model outperforms the compared models/settings.

Indexed as

Breast cancerDeep learningDigital mammogramLongitudinal dataRisk prediction

Identifiers

PMID37089470
PMCPMC10121208
OpenAlexW4286567656

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.