Evidence map›Paper›PMID 37089449›Full record

ArticleOncoimmunology2023

Neoadjuvant immune checkpoint blockade triggers persistent and systemic T

Olga S Blomberg, Kevin Kos, Lorenzo Spagnuolo, Olga I Isaeva, Hannah Garner, Max D Wellenstein, Noor Bakker, Danique E M Duits, Kelly Kersten, Sjoerd Klarenbeek and 6 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 56 citations in OpenAlex.

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  12. The Tumor Immune Microenvironment in Breast Cancer Progression.Acta oncologica (Stockholm, Sweden) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Olga S BlombergDivision of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Kevin KosDivision of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Lorenzo SpagnuoloDivision of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Olga I IsaevaDivision of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Hannah GarnerDivision of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Max D WellensteinDivision of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Noor BakkerDivision of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Danique E M DuitsDivision of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Kelly KerstenDivision of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Sjoerd KlarenbeekExperimental Animal Pathology Facility, Netherlands Cancer Institute, Amsterdam, Netherlands.
Cheei-Sing HauDivision of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Daphne KaldenbachDivision of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Elisabeth A M RaevenDivision of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Kim VrijlandDivision of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Marleen KokDivision of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Karin E de VisserDivision of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0002-0293-868X
The Netherlands Cancer Institute · NLLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical successes of immune checkpoint blockade (ICB) in advanced cancer patients have recently spurred the clinical implementation of ICB in the neoadjuvant and perioperative setting. However, how neoadjuvant ICB therapy affects the systemic immune landscape and metastatic spread remains to be established. Tumors promote both local and systemic expansion of regulatory T cells (T

Indexed as

Breast NeoplasmsLymphocyte ActivationT-Lymphocytes, RegulatoryAnimalsCD8-Positive T-LymphocytesHumansImmune Checkpoint InhibitorsKiller Cells, NaturalMiceMyeloid CellsNeoadjuvant TherapyNeoplasm MetastasisImmune Checkpoint InhibitorsBreast cancer metastasismyeloid cellsneoadjuvant immune checkpoint blockaderegulatory T cellsresistance mechanisms

Identifiers

PMID37089449
PMCPMC10114978
OpenAlexW4365515216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.