Evidence map›Paper›PMID 37089293›Full record

ArticleHeliyon2023

A canine thromboembolic model of anterior circulation large vessel occlusion stroke.

Amanda S Zakeri, Debra G Wheeler, Allyson Huttinger, Arianna Carfora, Aarushi Kini, Taggart Stork, Simon Yacoub, Cole Anderson, Matthew Joseph, Mohammed T Shujaat and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Amanda S ZakeriDepartment of Neurosurgery, The Ohio State University Medical Center, Columbus, OH, USA.
Debra G WheelerDepartment of Neurosurgery, The Ohio State University Medical Center, Columbus, OH, USA.
Allyson HuttingerDepartment of Neurosurgery, The Ohio State University Medical Center, Columbus, OH, USA.
Arianna CarforaDepartment of Neurosurgery, The Ohio State University Medical Center, Columbus, OH, USA.
Aarushi KiniDepartment of Neurosurgery, The Ohio State University Medical Center, Columbus, OH, USA.
Taggart StorkDepartment of Neurosurgery, The Ohio State University Medical Center, Columbus, OH, USA.
Simon YacoubDepartment of Neurosurgery, The Ohio State University Medical Center, Columbus, OH, USA.
Cole AndersonDepartment of Neurosurgery, The Ohio State University Medical Center, Columbus, OH, USA.
Matthew JosephDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH, USA.
Mohammed T ShujaatDepartment of Radiology, The Ohio State University Medical Center, Columbus, OH, USA.
Shahid M NimjeeDepartment of Neurosurgery, The Ohio State University Medical Center, Columbus, OH, USA.
The Ohio State University Wexner Medical Center · US

Funding

A Novel Thrombolytic Targeting Von Willebrand Factor (VWF) to Treat Ischemic StrokeR01NS123687 · NINDS · OHIO STATE UNIVERSITY · PI NIMJEE, SHAHID · 2021 to 2025
$2.5M
NINDS NIH HHS R01 NS123687
6 · The paper itself

Abstract

Purpose: To develop a large animal preclinical model of thromboembolic stroke with stable, protracted large vessel occlusion (LVO) utilizing an autologous clot. Materials and methods: A reproducible canine model of large vessel occlusion stroke was established by endovascular placement of an autologous clot into the middle cerebral artery (MCA) of six adult hounds and confirmed using digital subtraction angiography (DSA). Infarct volume and evidence of hemorrhage were determined by magnetic resonance imaging (MRI) 7 h after occlusion and Thrombolysis in Cerebral Infarction scale (TICI) was assessed before and after clot placement and at 1, 6, 7, and 9 h after middle cerebral artery occlusion (MCAO). Heart rate (HR) and blood pressure (BP) were monitored continuously and invasively through an arterial sheath throughout the procedures and complete blood count and blood gas analysis completed at time of sacrifice. Histopathological findings at time of sacrifice were used to confirm stroke volume and hemorrhage. Results: MCAO with resulting TICI 0 flow was observed in all six animals, verified by serial DSA, and lack of collateral flow persisted for 9 h after clot placement until time of sacrifice. The mean infarct volume was 47.0 ± 6.7% of the ipsilateral hemisphere and no events of spontaneous recanalization or clot autolysis were observed. Conclusion: We demonstrate a thromboembolic canine model of MCAO that is both feasible and results in consistent infarct volumes to generate a clinically relevant LVO. This model is important to evaluate treatment of LVO in acute ischemic stroke (AIS) outside the established 4.5 h recombinant tissue plasminogen activator (rTPA) therapeutic window utilizing a prolonged occlusive thrombus.

Indexed as

Canine modelMiddle cerebral artery occlusionStroke

Identifiers

PMID37089293
PMCPMC10119506
OpenAlexW4362453835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.