Evidence map›Paper›PMID 37088987›Full record

ArticleCell transplantation

Expandable Sendai-Virus-Reprogrammed Human iPSC-Neuronal Precursors:

Yoshiomi Kobayashi, Michiko Shigyo, Oleksandr Platoshyn, Silvia Marsala, Tomohisa Kato, Naoki Takamura, Kenji Yoshida, Akiyoshi Kishino, Mariana Bravo-Hernandez, Stefan Juhas and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

Yoshiomi KobayashiDepartment of Anesthesiology, School of Medicine, University of California, San Diego, San Diego, CA, USA.
Michiko ShigyoDepartment of Anesthesiology, School of Medicine, University of California, San Diego, San Diego, CA, USA.
Oleksandr PlatoshynDepartment of Anesthesiology, School of Medicine, University of California, San Diego, San Diego, CA, USA.
Silvia MarsalaDepartment of Anesthesiology, School of Medicine, University of California, San Diego, San Diego, CA, USA.
Tomohisa KatoRegenerative & Cellular Medicine Kobe Center, Sumitomo Dainippon Pharma Co., Ltd., Kobe, Japan.
Naoki TakamuraRegenerative & Cellular Medicine Kobe Center, Sumitomo Dainippon Pharma Co., Ltd., Kobe, Japan.
Kenji YoshidaRegenerative & Cellular Medicine Kobe Center, Sumitomo Dainippon Pharma Co., Ltd., Kobe, Japan.
Akiyoshi KishinoRegenerative & Cellular Medicine Kobe Center, Sumitomo Dainippon Pharma Co., Ltd., Kobe, Japan.
Mariana Bravo-HernandezDepartment of Anesthesiology, School of Medicine, University of California, San Diego, San Diego, CA, USA.
Stefan JuhasInstitute of Animal Physiology and Genetics, AS CR v.v.i., Liběchov, Czech Republic.
Jana JuhasovaInstitute of Animal Physiology and Genetics, AS CR v.v.i., Liběchov, Czech Republic.
Hana StudenovskaDepartment of Biomaterials and Bioanalogous System, Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic.
Vladimir ProksDepartment of Biomaterials and Bioanalogous System, Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic.
Shawn P DriscollGene Expression Laboratory, Howard Hughes Medical Institute and Salk Institute for Biological Studies, La Jolla, CA, USA.
Thomas D GlennGene Expression Laboratory, Howard Hughes Medical Institute and Salk Institute for Biological Studies, La Jolla, CA, USA.
Samuel L PfaffGene Expression Laboratory, Howard Hughes Medical Institute and Salk Institute for Biological Studies, La Jolla, CA, USA.
Joseph D CiacciDepartment of Neurosurgery, School of Medicine, University of California, San Diego, San Diego, CA, USA.
Martin MarsalaDepartment of Anesthesiology, School of Medicine, University of California, San Diego, San Diego, CA, USA.ORCID 0000-0001-5048-6422
University of California San Diego · USSalk Institute for Biological Studies · USSumitomo Dainippon Pharma (Japan) · JPCzech Academy of Sciences, Institute of Animal Physiology and Genetics · CZCzech Academy of Sciences, Institute of Macromolecular Chemistry · CZKanazawa Medical University · JPKeio University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the challenges in clinical translation of cell-replacement therapies is the definition of optimal cell generation and storage/recovery protocols which would permit a rapid preparation of cell-treatment products for patient administration. Besides, the availability of injection devices that are simple to use is critical for potential future dissemination of any spinally targeted cell-replacement therapy into general medical practice. Here, we compared the engraftment properties of established human-induced pluripotent stem cells (hiPSCs)-derived neural precursor cell (NPCs) line once cells were harvested fresh from the cell culture or previously frozen and then grafted into striata or spinal cord of the immunodeficient rat. A newly developed human spinal injection device equipped with a spinal cord pulsation-cancelation magnetic needle was also tested for its safety in an adult immunosuppressed pig. Previously frozen NPCs showed similar post-grafting survival and differentiation profile as was seen for freshly harvested cells. Testing of human injection device showed acceptable safety with no detectable surgical procedure or spinal NPCs injection-related side effects.

Indexed as

Cellular ReprogrammingInduced Pluripotent Stem CellsInjections, SpinalNeural Stem CellsStem Cell TransplantationAdultAnimalsBrainCell DifferentiationGenetic VectorsGraft SurvivalHumansRatsSendai virusSpecimen HandlingSpinal Cordcryopreservationhuman induced pluripotent stem cells (hiPSCs)human injection deviceimmunosuppressed adult pigneural precursor cells (NPCs)spinal cord

Identifiers

PMID37088987
PMCPMC10134149
OpenAlexW4366822247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.