Evidence map›Paper›PMID 37088786›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Fast Delivery of Multifunctional NIR-II Theranostic Nanoaggregates Enabled by the Photoinduced Thermoacoustic Process.

Huilin Xie, Chen Zhang, Tingting Li, Lianrui Hu, Jianquan Zhang, Heng Guo, Zhao Liu, Dinglu Peng, Zeshun Li, Weijun Wu and 10 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Huilin XieDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, 999077, China.ORCID 0000-0001-6685-5464
Chen ZhangDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, 999077, China.
Tingting LiShenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, Guangdong, 518055, China.
Lianrui HuDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, 999077, China.
Jianquan ZhangDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, 999077, China.
Heng GuoShenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, Guangdong, 518055, China.
Zhao LiuShenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, Guangdong, 518055, China.
Dinglu PengShenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, Guangdong, 518055, China.
Zeshun LiShenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, Guangdong, 518055, China.
Weijun WuShenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, Guangdong, 518055, China.
Ji GaoShenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, Guangdong, 518055, China.
Zhenyu BiShenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, Guangdong, 518055, China.
Jinghan WangShenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, Guangdong, 518055, China.
Pengfei ZhangGuangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, CAS-HK Joint Lab for Biomaterials, Research Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, CAS Key Lab for Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.
Ryan T K KwokDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, 999077, China.
Jacky W Y LamDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, 999077, China.
Zhihong GuoDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, 999077, China.
Lei XiShenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, Guangdong, 518055, China.
Kai LiShenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, Guangdong, 518055, China.
Ben Zhong TangDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, 999077, China.ORCID 0000-0002-0293-964X

Funding

Department of Science and Technology of Guangdong Province 2019QN01Y640Department of Science and Technology of Guangdong Province 2019ZT08Y191Guangdong Provincial Key Laboratory of Advanced Biomaterials 2022B1212010003Innovation and Technology Commission ITC-CNERC14SC01Innovation and Technology Commission MHP/047/19National Natural Science Foundation of China U21A2097Research Grants Council of Hong Kong 16303221Research Grants Council of Hong Kong 16306620Research Grants Council of Hong Kong C6014-20 WResearch Grants Council of Hong Kong N_HKUST609/19Science Technology Innovation Commission of Shenzhen Municipality JCYJ20220818103007014Science Technology Innovation Commission of Shenzhen Municipality KQTD20210811090142053Shenzhen Key Laboratory of Functional Aggregate Materials ZDSYS20211021111400001Shenzhen Key Laboratory of Smart Healthcare Engineering ZDSYS20200811144003009Shenzhen Science and Technology Program JCYJ20190809154011696Shenzhen Science and Technology Program JSGG20200225151916021Shenzhen Science and Technology Program KQTD20190929172743294
6 · The paper itself

Abstract

Multifunctional nanoaggregates are widely used in cancer phototheranostics. However, it is challenging to construct their multifunctionality with a single component, and deliver them rapidly and efficiently without complex modifications. Herein, a NIR-absorbing small molecule named TBT-2(TP-DPA) is designed and certify its theranostic potentials. Then, their nanoaggregates, which are simply encapsulated by DSPE-PEG, demonstrate a photothermal efficiency of 51% while keeping a high photoluminescence quantum yield in the NIR region. Moreover, the nanoaggregates can be excited and delivered by an 808 nm pulse laser to solid tumors within only 40 min. The delivery efficiency and theranostic efficacy are better than that of the traditional enhanced permeability and retention (EPR) effect (generally longer than 24 hours). This platform is first termed as the photoinduced thermoacoustic (PTA) process, and confirm its application requires both NIR-responsive materials and pulse laser irradiation. This study not only inspires the design of multifunctional nanoaggregates, but also offers a feasible approach to their fast delivery. The platform reported here provides a promising prospect to boost the development of multifunctional theranostic drugs and maximize the efficacy of used medicines for their clinical applications.

Indexed as

NeoplasmsPrecision MedicineHumansTheranostic Nanomedicineaggregation-induced emissionnanoaggregate fast deliveryphotoinduced thermoacoustic processphototheranostic agent

Identifiers

PMID37088786
PMCPMC10323613

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.