Evidence map›Paper›PMID 37088731›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Liquid NanoBiosensors Enable One-Pot Electrochemical Detection of Bacteria in Complex Matrices.

Sara M Imani, Enas Osman, Fatemeh Bakhshandeh, Shuwen Qian, Sadman Sakib, Michael MacDonald, Mark Gaskin, Igor Zhitomirsky, Deborah Yamamura, Yingfu Li and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Sara M ImaniSchool of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada.
Enas OsmanSchool of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada.
Fatemeh BakhshandehDepartment of Engineering Physics, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada.
Shuwen QianDepartment of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4L8, Canada.
Sadman SakibDepartment of Engineering Physics, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada.
Michael MacDonaldDepartment of Materials Science and Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4L8, Canada.
Mark GaskinHamilton Regional Laboratory Medicine Program, Hamilton General Hospital, 237 Barton St. East, Hamilton, Ontario, L8L 2×2, Canada.
Igor ZhitomirskySchool of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada.
Deborah YamamuraDepartment of Pathology and Molecular Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada.
Yingfu LiSchool of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada.
Tohid F DidarSchool of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada.
Leyla SoleymaniSchool of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7, Canada.ORCID 0000-0003-4915-2999
McMaster University · CAHamilton General Hospital · CA

Funding

Canada Research ChairsNSERCOntario Ministry of Research and Innovation
6 · The paper itself

Abstract

There is a need for point-of-care bacterial sensing and identification technologies that are rapid and simple to operate. Technologies that do not rely on growth cultures, nucleic acid amplification, step-wise reagent addition, and complex sample processing are the key for meeting this need. Herein, multiple materials technologies are integrated for overcoming the obstacles in creating rapid and one-pot bacterial sensing platforms. Liquid-infused nanoelectrodes are developed for reducing nonspecific binding on the transducer surface; bacterium-specific RNA-cleaving DNAzymes are used for bacterial identification; and redox DNA barcodes embedded into DNAzymes are used for binding-induced electrochemical signal transduction. The resultant single-step and one-pot assay demonstrates a limit-of-detection of 10

Indexed as

DNA, CatalyticEscherichia coliBacteriaDNASensitivity and SpecificityDNADNA, Catalyticbacteria detectionDNAzymeselectrochemical biosensorsliquid-infused surfacesurinary tract infections

Identifiers

PMID37088731
PMCPMC10323635
OpenAlexW4366783097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.