Effect of Bisphosphonate and Active Vitamin D Analog on Glucocorticoid-induced Osteoporosis in Patients with IgA Nephropathy: A Retrospective Observational Study.

Rie Takiguchi, Shinichi Nishi, Shunsuke Goto, Hideki Fujii

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In one paragraph

Observational study in The Kobe journal of medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rie TakiguchiDivision of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Kobe, Japan.

Shinichi NishiDivision of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Kobe, Japan.

Shunsuke GotoDivision of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Kobe, Japan.

Hideki FujiiDivision of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Kobe, Japan.

Kobe University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Few studies on glucocorticoid (GC)-induced osteoporosis exist in IgA nephropathy (IgAN). Here we aimed to compare the effects of bisphosphonate (Bis) and active vitamin D analog (Vit. D) in maintaining bone mineral density (BMD) in patients with IgAN. This study is a retrospective observational one. Between April 2007 and December 2014, a total of 127 patients with IgAN received GC treatment at Kobe University Hospital. Among them, we measured the BMD of 48 patients with a mean age of approximately 30 years, before and after GC treatment. The %ΔBMD of the lumber spine increased in the Bis group (1.6% ± 2.3%), but decreased in the Vit. D group (-3.3% ± 3.6%). The %ΔBMD of the two groups differed significantly (p < 0.05). Although the %ΔBMD of the femoral neck showed the same tendency, the difference between two groups was not significant. Bis was significantly superior to Vit. D in maintaining the BMD of lumbar spine bones. Even in young patients with IgAN, Bis is recommended to prevent the reduction of BMD during GC treatment.

Indexed as

Glomerulonephritis, IGAOsteoporosisAdultBone DensityDiphosphonatesGlucocorticoidsHumansRetrospective StudiesVitamin DDiphosphonatesGlucocorticoidsVitamin DActive vitamin D analogBisphosphonateBone mineral densityGlucocorticoid-induced osteoporosisIgA nephropathy

Identifiers

PMID37088694

PMCPMC10128593

OpenAlexW4366821760

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.