ArticleEBioMedicine2023
Umbilical cord DNA methylation is associated with body mass index trajectories from birth to adolescence.
Article in EBioMedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Differential methylation at novel putative imprinting control regions on chromosome 20 associated with childhood obesity.Epigenetics · 2026Article
- Mitochondrial signatures of infant mesenchymal stem cells predict child adiposity: The Healthy Start Study.Research square · 2026Article
- Cord Blood DNA Methylation at CHD13 Is Associated with Adiponectin Levels at 10 to 14 Years of Age.The Journal of clinical endocrinology and metabolism · 2026Article
- Maternal history of maltreatment interacts with DNA methylation patterns to predict infant temperament.Child abuse & neglect · 2025Article
- Breadth versus depth: balancing variables, sample size, and quality in Chinese cohort studies.BMJ (Clinical research ed.) · 2025Article
- Article
- Prenatal black carbon exposure and DNA methylation in umbilical cord blood.International journal of hygiene and environmental health · 2025Article
- Review
- Newborn DNA methylation age differentiates long-term weight trajectories: the Boston Birth Cohort.BMC medicine · 2024Article
- [A prospective cohort study of association between early childhood body mass index trajectories and the risk of overweight].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Maternal obesity and placental function: impaired maternal-fetal axis.Archives of gynecology and obstetrics · 2024Review
- From womb to wellness: early environmental exposures, cord blood DNA methylation and disease origins.Epigenomics · 2024Review
- Differentially methylated regions interrogated for metastable epialleles associate with offspring adiposity.Epigenomics · 2024Article
- Early Life Origins of Cardio-Metabolic Outcomes in Boston Birth Cohort: Review of Findings and Future directions.Precision nutrition · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundDNA methylation (DNAm) in cord blood has been associated with various prenatal factors and birth outcomes. This study sought to fill an important knowledge gap: the link of cord DNAm with child postnatal growth trajectories from birth to age 18 years (y).
methodsUsing data from a US predominantly urban, low-income, multi-ethnic birth cohort (N = 831), we first applied non-parametric methods to identify body-mass-index percentile (BMIPCT) trajectories from birth to age 18 y (the outcome); then, conducted epigenome-wide association study (EWAS) of the outcome, interrogating over 700,000 CpG sites profiled by the Illumina Infinium MethylationEPIC BeadChip. Multivariate linear regression models and likelihood ratio tests (LRT) were applied to examine the DNAm-outcome association in the overall sample and sex strata.
findingsWe identified four distinct patterns of BMIPCT trajectories: normal weight (NW), Early overweight or obesity (OWO), Late OWO, and normal to very late OWO. DNAm at CpG18582997 annotated to TPGS1, CpG15241084 of TLR7, and cg24350936 of RAB31 were associated with BMIPCT at birth-to-3 y, 10 y, and 14 y, respectively (LRT FDR < 0.05 for all).
interpretationIn this prospective birth cohort study, we identified 4 distinct and robust patterns of growth trajectories from birth to 18 y, which were associated with variations in cord blood DNAm at genes implicated in inflammation induction pathways. These findings, if further replicated, raise the possibility that these DNAm markers along with early assessment of BMIPCT trajectories may help identify young children at high-risk for obesity later in life.
fundingDetailed in the Acknowledgements section.
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