[Multiple primary malignancies combined with SWI/SNF complex-deficient gastric cancer: a case report and literature review].

C Lü, X Wu, Q Xia

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In one paragraph

Review in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

C LüDepartment of Oncology, Punan Hospital of Pudong New District, Shanghai 200120, China.

X WuDepartment of Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200120, China.

Q XiaDepartment of Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200120, China.

Renji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple primary malignancies combined with SWI/SNF complex-deficient gastric cancer is a rare clinical entity and poorly documented. Herein we report a case of this disease in an 81-year-old male patient treated in our hospital. Before the established diagnosis of metachronous multiple primary malignancies, the patient received left lower lobectomy for a spaceoccupying mass in the left lung, which was confirmed by postoperative pathology as early stage lung cancer. SWI/SNF complex-deficiency gastric cancer with metastasis was subsequently detected by gastroscopy, and high-throughput sequencing identified ARID1A and TMB-H gene mutations in the tumor tissues. The patient received chemotherapy combined with immunotherapy but failed to respond to the treatment, and died 13 months later. We conducted a literature review and analyzed the occurrence, pathological and immunohistochemical characteristics, diagnosis, treatment and prognosis of this disease.

Indexed as

Neoplasms, Multiple PrimaryStomach NeoplasmsAged, 80 and overHumansMaleMutationNuclear ProteinsNuclear Proteinsgastric cancermultiple primary malignanciesSWI/SNF complex-deficiency

Identifiers

PMID37087597

DOI10.12122/j.issn.1673-4254.2023.03.22

PMCPMC10122742

OpenAlexW4366776504

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.