ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023
[CD5L is elevated in the serum of patients with candidemia and promotes disease progression in mouse models].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors at 1 institution in 1 country.
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Abstract
objectiveTo investigate the changes of CD5L levels in patients with candidemia and explore the role of CD5L in progression of candidemia.
methodsTwenty healthy control individuals, 27 patients with bacteremia and 35 patients with candidemia were examined for serum CD5L levels using ELISA, and the correlations of CD5L level with other serological indicators were analyzed. A C57BL/6 mouse model of candidemia induced by intravenous injection of
resultsCD5L levels were significantly elevated in patients with candidemia and positively correlated with WBC, BDG, Scr and PCT levels. The mouse model of candidemia also showed significantly increased serum and renal CD5L levels, and CD5L treatment significantly increased fungal burden in the renal tissue, elevated IL-6 and IL-8 levels in the serum and kidney, aggravated renal tissue damage, and reduced survival rate of candidemia mice.
conclusionSerum CD5L levels are increased in patients with candidemia, and treatment with CD5L aggravates candidemia in mouse models.
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