Evidence map›Paper›PMID 37087539›Full record

ArticlePediatric research2024

Extracorporeal life support without systemic anticoagulation: a nitric oxide-based non-thrombogenic circuit for the artificial placenta in an ovine model.

Brian P Fallon, Orsolya Lautner-Csorba, Terry C Major, Gergely Lautner, Stephen L Harvey, Mark W Langley, Matthew D Johnson, Claudia Saveski, Niki Matusko, Raja Rabah and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
10.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Extracorporeal Support Vascular Access: 3D Printing Custom Cannulas.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Artificial womb technology - A more physiologic solution to treating extreme prematurity.European journal of obstetrics & gynecology and reproductive biology: X · 2025
    Review
  7. Antithrombotic and Antimicrobial Potential of S -Nitroso-1-Adamantanethiol-Impregnated Extracorporeal Circuit.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2025
    Article
  8. Feasibility of controlled nitric oxide generationDalton transactions (Cambridge, England : 2003) · 2025
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Brian P FallonDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA. bfallon@med.umich.edu.ORCID 0000-0002-5211-2528
Orsolya Lautner-CsorbaDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.
Terry C MajorDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.
Gergely LautnerDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.
Stephen L HarveyDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.
Mark W LangleyDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.
Matthew D JohnsonDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.
Claudia SaveskiDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.
Niki MatuskoDepartment of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
Raja RabahDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Alvaro Rojas-PenaDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.
Mark E MeyerhoffDepartment of Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA.
Robert H BartlettDepartment of Surgery, ECLS Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.
George B MychaliskaDepartment of Surgery, Section of Pediatric Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
University of Michigan · US

Funding

Development of an Artificial Placenta for Support of Premature InfantsR01HD073475 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYCHALISKA, GEORGE BORIS · 2014 to 2018
$2.7M
NICHD NIH HHS R01 HD073475
6 · The paper itself

Abstract

backgroundClinical translation of the extracorporeal artificial placenta (AP) is impeded by the high risk for intracranial hemorrhage in extremely premature newborns. The Nitric Oxide Surface Anticoagulation (NOSA) system is a novel non-thrombogenic extracorporeal circuit. This study aims to test the NOSA system in the AP without systemic anticoagulation.

methodsTen extremely premature lambs were delivered and connected to the AP. For the NOSA group, the circuit was coated with DBHD-N

resultsAnimals survived 6.8 ± 0.6 days with normal hemodynamics and gas exchange. Neither group had any hemorrhagic or thrombotic complications. ACT (194 ± 53 vs. 261 ± 86 s; p < 0.001) and aPTT (39 ± 7 vs. 69 ± 23 s; p < 0.001) were significantly lower in the NOSA group than the Heparin group. Platelet and leukocyte activation did not differ significantly from baseline in the NOSA group. Methemoglobin was 3.2 ± 1.1% in the NOSA group compared to 1.6 ± 0.6% in the Heparin group (p < 0.001).

conclusionsThe AP with the NOSA system successfully supported extremely premature lambs for 7 days without significant bleeding or thrombosis. IMPACT: The Nitric Oxide Surface Anticoagulation (NOSA) system provides effective circuit-based anticoagulation in a fetal sheep model of the extracorporeal artificial placenta (AP) for 7 days. The NOSA system is the first non-thrombogenic circuit to consistently obviate the need for systemic anticoagulation in an extracorporeal circuit for up to 7 days. The NOSA system may allow the AP to be implemented clinically without systemic anticoagulation, thus greatly reducing the intracranial hemorrhage risk for extremely low gestational age newborns. The NOSA system could potentially be applied to any form of extracorporeal life support to reduce or avoid systemic anticoagulation.

Indexed as

Extracorporeal Membrane OxygenationPremature BirthThrombosisAnimalsAnticoagulantsFemaleHemorrhageHeparinHumansIntracranial HemorrhagesNitric OxidePlacentaPregnancySheepAnticoagulantsHeparinNitric Oxide

Identifiers

PMID37087539
PMCPMC10600655
OpenAlexW4366758153

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.