Evidence map›Paper›PMID 37087526›Full record

ArticleGenes and environment : the official journal of the Japanese Environmental Mutagen Society2023

DNA polymerase κ suppresses inflammation and inflammation-induced mutagenesis and carcinogenic potential in the colon of mice.

Atsushi Hakura, Hajime Sui, Yuki Seki, Jiro Sonoda, Yusaku Yoshida, Hisayoshi Takagi, Shigeo Yokose, Tomonari Matsuda, Shoji Asakura, Takehiko Nohmi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Mitomycin C-induced DNA double-strand breaks are enhanced by catalytical inactivation of DNA polymerase κ in mice.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Atsushi HakuraGlobal Drug Safety, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba-Shi, Ibaraki, 300-2635, Japan. a-hakura@hhc.eisai.co.jp.ORCID http://orcid.org/0000-0002-5834-1284
Hajime SuiDivision of Safety Testing, Food and Drug Safety Center, Hatano Research Institute, Hadano, Kanagawa, 257-0025, Japan.
Yuki SekiGlobal Drug Safety, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba-Shi, Ibaraki, 300-2635, Japan.
Jiro SonodaGlobal Drug Safety, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba-Shi, Ibaraki, 300-2635, Japan.
Yusaku YoshidaBiotechnical Center, Japan SLC, Inc., 3-5-1 Aoihigashi, Naka-Ku, Hamamatsu-Shi, Shizuoka, 433-8114, Japan.
Hisayoshi TakagiBiotechnical Center, Japan SLC, Inc., 3-5-1 Aoihigashi, Naka-Ku, Hamamatsu-Shi, Shizuoka, 433-8114, Japan.
Shigeo YokoseBiotechnical Center, Japan SLC, Inc., 3-5-1 Aoihigashi, Naka-Ku, Hamamatsu-Shi, Shizuoka, 433-8114, Japan.
Tomonari MatsudaResearch Center for Environmental Quality Management, Kyoto University, Otsu, Shiga, 520-0811, Japan.
Shoji AsakuraGlobal Drug Safety, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba-Shi, Ibaraki, 300-2635, Japan.
Takehiko NohmiDivision of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-Ku, Kawasaki-Shi, Kanagawa, 210-9501, Japan. nohmi@nihs.go.jp.ORCID http://orcid.org/0000-0002-4729-6334
Eisai (Japan) · JPFood and Drug Safety Center · JPKyoto University · JPNational Institute of Health Sciences · JP

Funding

Japan Society for the Promotion of Science 26281029
6 · The paper itself

Abstract

backgroundChronic inflammation induces DNA damage and promotes cell proliferation, thereby increasing the risk of cancer. DNA polymerase κ (Pol κ), involved in translesion DNA synthesis, counteracts mutagenesis induced by inflammation in the colon of mice. In the present study, we examined whether Pol κ suppressed inflammation-induced colon tumorigenesis by treating inactivated Polk knock-in (Polk

resultsMale and female Polk

conclusionsPol κ suppresses inflammation and inflammation-induced dysplasia as well as inflammation-induced mutagenesis. The possible mechanisms by which Pol κ suppresses colitis- and colitis-induced dysplasia are discussed.

Indexed as

Chronic inflammationColitisDNA damageDNA polymerase κDysplasiaIn vivo mutationTranslesion DNA synthesis

Identifiers

PMID37087526
PMCPMC10122296
OpenAlexW4366770018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.