ArticleNature communications2023
Nickel/biimidazole-catalyzed electrochemical enantioselective reductive cross-coupling of aryl aziridines with aryl iodides.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Photoinduced cobalt-catalyzed enantioconvergent synthesis of 1,3-diamines via aziridine ring-opening addition.Science advances · 2026Article
- Base-Free C-N Cross-Electrophile Coupling.Journal of the American Chemical Society · 2026Article
- Enantio- and regioselective nickel/photoredox-catalyzed cross-electrophile coupling of benzylic aziridines with alkynyl bromides.Science advances · 2026Article
- Applying asymmetric-waveform alternating current in nickel-catalyzed asymmetric reductive cross-coupling.Nature communications · 2026Article
- Electrochemical hydroxylation of alkenes with HNational science review · 2026Article
- Article
- Dual Catalytic Enantioconvergent Carbamoylation of Aziridines.Journal of the American Chemical Society · 2025Article
- Recent Advancements in Nickel-Catalyzed Electrochemical Reductive Cross-Coupling.ACS organic & inorganic Au · 2025Review
- Electrochemical Enantioselective Oxidation of Indoles via Chiral Phosphoric Acid Catalysis in Cooperation with HAngewandte Chemie (International ed. in English) · 2025Article
- Transition Metal Catalysis for the Asymmetric Synthesis of 2-Arylethylamines: A Review of the New Millennium.Molecules (Basel, Switzerland) · 2025Review
- Enantioselective reductive cross-couplings to forge C(spNature communications · 2025Article
- Electrochemical Enantioselective Nickel-Catalyzed Cross-Coupling of Aldehydes with Aryl Iodides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Electrochemically Driven Nickel-Catalyzed Enantioselective Hydro-Arylation/Alkenylation of Enones.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Ni-Catalyzed Asymmetric Reductive Arylation of α-Substituted Imides.Journal of the American Chemical Society · 2024Article
- The merger of electro-reduction and hydrogen bonding activation for a radical Smiles rearrangement.Chemical science · 2024Article
- Photoelectrochemical Ni-catalyzed cross-coupling of aryl bromides with amine at ultra-low potential.Nature communications · 2024Article
- β-Phenethylamine Synthesis: N-Pyridinium Aziridines as Latent Dual Electrophiles.Angewandte Chemie (International ed. in English) · 2024Article
- Reaction-Agnostic Featurization of Bidentate Ligands for Bayesian Ridge Regression of Enantioselectivity.ACS catalysis · 2024Article
- Enantioselective nickel-catalyzed anodic oxidative dienylation and allylation reactions.Nature communications · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Here, we report an asymmetric electrochemical organonickel-catalyzed reductive cross-coupling of aryl aziridines with aryl iodides in an undivided cell, affording β-phenethylamines in good to excellent enantioselectivity with broad functional group tolerance. The combination of cyclic voltammetry analysis of the catalyst reduction potential as well as an electrode potential study provides a convenient route for reaction optimization. Overall, the high efficiency of this method is credited to the electroreduction-mediated turnover of the nickel catalyst instead of a metal reductant-mediated turnover. Mechanistic studies suggest a radical pathway is involved in the ring opening of aziridines. The statistical analysis serves to compare the different design requirements for photochemically and electrochemically mediated reactions under this type of mechanistic manifold.
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Registered trials
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