ArticleMicrobiome2023
The hindgut microbiome contributes to host oxidative stress in postpartum dairy cows by affecting glutathione synthesis process.
Article in Microbiome, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 91 citations in OpenAlex.
- Gut microbiota-regulated glutathione metabolic rhythms restore obesity-induced colonic inflammatory oscillations.Gut microbes · 2026Article
- Mechanisms Underlying the Impact of Feed-to-Gain Ratio Differences on Nutrient Metabolism in Simmental and Simmental × Hereford Crossbred Cattle Fed a Low-Energy Diet.Animals : an open access journal from MDPI · 2026Article
- Optimal dietary nano-VD₃ enhances growth performance and bone development in broilers through remodeling the gut microbiome and metabolites.BMC veterinary research · 2026Article
- Peripartum hypophosphatemia is associated with a hindgut-centered microbiota-metabolite-host axis in transition dairy cows.NPJ biofilms and microbiomes · 2026Article
- Glutamine and Its Precursors Supplementation Improve Growth Performance and Immunity and Regulate Gastrointestinal Microbiota of Suckling Lambs.Life (Basel, Switzerland) · 2026Article
- Multi-omics reveals effects of several rumen bacteria on reproductive performance of sheep.Microbiome · 2026Article
- Microbial landscapes in dairy cow diseases: from localized dysbiosis to inter-organ axes.NPJ biofilms and microbiomes · 2026Review
- Microbiota-gut-muscle axis shapes fish muscle texture by regulating collagen synthesis.Microbiome · 2026Article
- Oral microbiome perturbations link periodontal health to cognitive ageing in a large community cohort.EBioMedicine · 2026Article
- Diet-Microbiome-Redox Interactions and Oxidative Stress Biomarkers in Livestock: Computational and Spatial Perspectives for Translational Health and Production.International journal of molecular sciences · 2026Review
- Rumen microbiota-associated stress alleviation by creatine pyruvate in newly received cattle: a multi-omics study.Microbiome · 2026Article
- Gut Microbial Composition, Oxidative Stress, and Immunity in Metabolic Disease: Toward Personalized Interventions.Antioxidants (Basel, Switzerland) · 2026Review
- A Novel Approach to Biodegradation and Detoxification of Ricinine in Castor Meal: Relationship Between the Gut Microbiota and Microbial Metabolites ofMicroorganisms · 2026Article
- Low-Dosage Rumen Unprotected Creatine Precursor During the Transition Period in Single-Bearing Ewes Impacts Dynamic Changes in Muscle and Adipose Mass, Uterine Involution, and Fetal Programming Outcomes.Veterinary sciences · 2026Article
- Multicellular Model Reveals the Mechanism of AEE Alleviating Vascular Endothelial Cell Injury via Anti-Inflammatory and Antioxidant Effects.International journal of molecular sciences · 2026Article
- Rumen microbiota modulates metabolic stress in high-yield dairy cows: insights from early to peak lactation.Microbiome · 2026Article
- Early antioxidant capacity, intestinal barrier integrity and gut microbiota drive DHAV-3 resistance in ducks.Journal of animal science and biotechnology · 2026Article
- The impact of rumen and hindgut microbiomes on the persistent productivity of long-lived dairy cows.Microbiome · 2026Article
- Preoperative gut microbiota combined with machine learning for predicting post-hepatectomy liver failure in HBV-related hepatocellular carcinoma: a pilot study.Frontiers in cellular and infection microbiology · 2026Article
- Influence of creatine pyruvate on newly received cattle: insights from metagenomics and metabolomics.BMC microbiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDairy cows are susceptible to postpartum systemic oxidative stress (OS), which leads to significant production loss and metabolic disorders. The gut microbiota has been linked to host health and stress levels. However, to what extent the gut microbiota is associated with postpartum OS remains unknown. In this study, the contribution of the fecal microbiota to postpartum systemic OS and its underlying mechanisms were investigated by integrating 16S rRNA gene sequencing, metagenomics, and metabolomics in postpartum dairy cattle and by transplanting fecal microbiota from cattle to mice.
resultsA strong link was found between fecal microbial composition and postpartum OS, with an explainability of 43.1%. A total of 17 significantly differential bacterial genera and 19 species were identified between cows with high (HOS) and low OS (LOS). Among them, 9 genera and 16 species showed significant negative correlations with OS, and Marasmitruncus and Ruminococcus_sp._CAG:724 had the strongest correlations. The microbial functional analysis showed that the fecal microbial metabolism of glutamine, glutamate, glycine, and cysteine involved in glutathione synthesis was lower in HOS cows. Moreover, 58 significantly different metabolites were identified between HOS and LOS cows, and of these metabolites, 19 were produced from microbiota or cometabolism of microbiota and host. Furthermore, these microbial metabolites were enriched in the metabolism of glutamine, glutamate, glycine, and cysteine. The mice gavaged with HOS fecal microbiota had significantly higher OS and lower plasma glutathione peroxidase and glutathione content than those orally administered saline or LOS fecal microbiota.
conclusionsIntegrated results suggest that the fecal microbiota is responsible for OS and that lower glutathione production plays a causative role in HOS. These findings provide novel insights into the mechanisms of postpartum OS and potential regulatory strategies to alleviate OS in dairy cows. Video Abstract.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.