Evidence map›Paper›PMID 37087394›Full record

ReviewBlood reviews2023

How do we improve the translation of new evidence into the practice of hematopoietic cell transplantation and cellular therapy?

Mark Juckett, Christopher Dandoy, Zachariah DeFilipp, Tamila L Kindwall-Keller, Stephen R Spellman, Celalettin Ustun, Bryce M Waldman, Daniel J Weisdorf, William A Wood, Mary M Horowitz and 2 more

Abstract readReview
In one paragraph

Review in Blood reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mark JuckettUniversity of Minnesota, Minneapolis, MN, United States of America.
Christopher DandoyUniversity of Cincinnati College of Medicine, Cincinnati, OH, United States of America.
Zachariah DeFilippMassachusetts General Hospital, Boston, MA, United States of America.
Tamila L Kindwall-KellerUniversity of Virginia, Charlottesville, VA, United States of America.
Stephen R SpellmanCIBMTR® (Center for International Blood and Marrow Transplant Research), Milwaukee, WI, United States of America.
Celalettin UstunRush University Medical Center, Chicago, IL, United States of America.
Bryce M WaldmanCenter for International Blood and Marrow Transplant, Milwaukee, WI, United States of America.
Daniel J WeisdorfUniversity of Minnesota, Minneapolis, MN, United States of America.
William A WoodUniversity of North Carolina, Chapel Hill, NC, United States of America.
Mary M HorowitzCIBMTR® (Center for International Blood and Marrow Transplant Research), Milwaukee, WI, United States of America; Medical College of Wisconsin, Milwaukee, WI, United States of America.
Linda J BurnsCIBMTR® (Center for International Blood and Marrow Transplant Research), Milwaukee, WI, United States of America.
Nandita KheraCollege of Medicine, Mayo Clinic, Phoenix, AZ, United States of America. Electronic address: khera.nandita@mayo.edu.

Funding

Blood and Marrow Transplant Clinical Trials Network DCC- The Medical College of Wisconsin, Inc.U24HL138660 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Steven M. DeVine, Mehdi Hussain Hamadani · 2017 to 2026
$71.4M
NHLBI NIH HHS U24 HL138660
6 · The paper itself

Abstract

The field of hematopoietic cell transplantation and cell therapy (HCT/CT) is advancing rapidly to bring an ever-expanding collection of potentially curative therapies to patients with malignant and non-malignant diseases. The impact of these therapies depends on our ability to implement them as new evidence becomes available to advance the quality of care. There is often a long delay between evidence development and adoption of therapies based on that evidence into clinical practice. In this review, we describe the potential factors based on an implementation framework that could act as facilitators or barriers to adoption of therapies in the context of HCT/CT. We highlight two examples, the first to showcase the efforts to improve the efficiency of adoption of new findings and accelerate improvement in care of HCT/CT patients and the second to discuss the challenges in real world implementation of chimeric antigen receptor T cell therapy. We conclude by reviewing strategies to improve translation of evidence and ways to measure their success.

Indexed as

Hematopoietic Stem Cell TransplantationHumansImmunotherapy, AdoptiveCellular therapyClinical trialsHematopoietic cell transplantationStandard practiceTranslation of evidence

Identifiers

PMID37087394
PMCPMC10330269

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.