Evidence map›Paper›PMID 37086720›Full record

ArticleCell metabolism2023

Biological age is increased by stress and restored upon recovery.

Jesse R Poganik, Bohan Zhang, Gurpreet S Baht, Alexander Tyshkovskiy, Amy Deik, Csaba Kerepesi, Sun Hee Yim, Ake T Lu, Amin Haghani, Tong Gong and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 1 pooled it
18.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 1 synthesis or guideline pooled it, 197 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Article
  9. Energy constraint on human health.Trends in endocrinology and metabolism: TEM · 2026
    Review
  10. Article
  11. Transplanted hearts assimilate the recipient's biological age.bioRxiv : the preprint server for biology · 2026
    Article
  12. The Hallmarks of Aging: From Molecular Mechanisms to Clinical Translation.International journal of molecular sciences · 2026
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Dilating the aging clock with light.Innovation (Cambridge (Mass.)) · 2026
    Review
  19. Review
  20. Article

79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 3 countries.

Jesse R PoganikDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Bohan ZhangDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Gurpreet S BahtDepartment of Orthopaedic Surgery, Duke University, Durham, NC 27701, USA; Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA.
Alexander TyshkovskiyDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Amy DeikBroad Institute of MIT and Harvard, Cambridge, MA 01241, USA.
Csaba KerepesiInstitute for Computer Science and Control (SZTAKI), Eötvös Loránd Research Network, Budapest, 1111, Hungary.
Sun Hee YimDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ake T LuDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Altos Labs, San Diego, CA, USA.
Amin HaghaniDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Altos Labs, San Diego, CA, USA.
Tong GongDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Anna M HedmanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Ellika AndolfDepartment of Clinical Sciences, Division of Obstetrics and Gynaecology, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
Göran PershagenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden.
Catarina AlmqvistDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Clary B ClishBroad Institute of MIT and Harvard, Cambridge, MA 01241, USA.
Steve HorvathDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Altos Labs, San Diego, CA, USA; Department of Biostatistics, School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA.
James P WhiteDuke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA; Department of Medicine, Duke University School of Medicine, Durham, NC 27701, USA. Electronic address: james.white@duke.edu.
Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 01241, USA. Electronic address: vgladyshev@rics.bwh.harvard.edu.
Karolinska Institutet · SEBroad Institute · USHarvard University · USAltos LabsDuke University · USBrigham and Women's Hospital · USCentre for Palaeogenetics · SEInstitute for Computer Science and Control · HUUniversity of California, Los Angeles · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Mechanisms of lifespan controlDP1AG047745 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI GLADYSHEV, VADIM N. · 2013 to 2018
$4.4M
QUANTITATIVE ASSESSMENT OF BIOLOGICAL AGE AND ITS APPLICATIONSR01AG065403 · NIA · YALE UNIVERSITY · PI Vadim N. Gladyshev, Albert Tzongyang Higgins-Chen · 2020 to 2026
$4.2M
Unbiased identification of interventions that extend lifespanR01AG067782 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI GLADYSHEV, VADIM N. · 2019 to 2023
$3.5M
Organ Design and Engineering Training Program (ODET Program)T32EB016652 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 2014 to 2023
$3.5M
Role of rare damaging mutations in agingR01AG064223 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI GLADYSHEV, VADIM N. · 2020 to 2024
$2.8M
Understanding the Causes of AgingR01AG038004 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI GLADYSHEV, VADIM N. · 2010 to 2013
$1.1M
Assessing healthspan and epigenetics in aged mice after prolonged exposure to young circulationR21AG065943 · NIA · DUKE UNIVERSITY · PI WHITE, JAMES P. · 2020 to 2021
$443k
Profiling epigenetic age in single cells and in a high-throughput mannerR56AG076607 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI GLADYSHEV, VADIM N. · 2022 to 2022
$310k
NIA NIH HHS DP1 AG047745NIA NIH HHS R01 AG038004NIA NIH HHS R01 AG064223NIA NIH HHS R01 AG065403NIA NIH HHS R01 AG067782NIA NIH HHS R21 AG065943NIA NIH HHS R56 AG076607NIBIB NIH HHS T32 EB016652NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. Here, we report that biological age is fluid and exhibits rapid changes in both directions. At epigenetic, transcriptomic, and metabolomic levels, we find that the biological age of young mice is increased by heterochronic parabiosis and restored following surgical detachment. We also identify transient changes in biological age during major surgery, pregnancy, and severe COVID-19 in humans and/or mice. Together, these data show that biological age undergoes a rapid increase in response to diverse forms of stress, which is reversed following recovery from stress. Our study uncovers a new layer of aging dynamics that should be considered in future studies. The elevation of biological age by stress may be a quantifiable and actionable target for future interventions.

Indexed as

COVID-19AgingAnimalsHumansMiceParabiosisagingbiological agedynamicsepigenetic aging clocksrecoverystress

Identifiers

PMID37086720
PMCPMC11055493
OpenAlexW4366693590

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.