Evidence map›Paper›PMID 37086299›Full record

ArticleMolecular biology reports2023

5-Aminolevulinic acid combined with ferrous iron ameliorates scrotal heat stress-induced spermatogenic damage by enhancing HO-1 expression.

Peng Gao, Jingming Zhuang, Haoran Chen, Zujun Fang, Jie Zheng, Daqian Zhu, Jiangang Hou

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. 5-ALA/FeFrontiers in cell and developmental biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Peng Gao *Department of Urology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jingming Zhuang *Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China.
Haoran ChenDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zujun FangDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jie ZhengDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Daqian ZhuNational Children's Medical Center, Children's Hospital of Fudan University, Shanghai, 201102, China.
Jiangang HouDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, 200040, China. hou_jiangang@126.com.
Huashan Hospital · CNFudan University · CNChildren's Hospital of Fudan University · CNShanghai First People's Hospital · CN

Funding

Shanghai's Healthcare System-Psychosomatic medicine No.2019ZB0203the national natural science foundation of China 81771683
6 · The paper itself

Abstract

objectiveTo explore whether 5-Aminolevulinic acid combined with ferrous iron (5-ALA/Fe

methods5-ALA/Fe

resultsCompared to control group, the testis weight decreased and histological damage severed in HS group. Besides, HS also increased the oxidative stress, apoptosis and inflammation in testis. However, these indicators were ameliorated after 5-ALA/Fe

conclusionIn this study, we have demonstrated that 5-ALA/Fe

Indexed as

Aminolevulinic AcidIronAnimalsApoptosisForkhead Transcription FactorsHeat-Shock ResponseHeme Oxygenase-1MaleMiceMitogen-Activated Protein KinasesOxidative StressAminolevulinic AcidForkhead Transcription FactorsHeme Oxygenase-1IronMitogen-Activated Protein Kinases5-Aminolevulinic acidCD4+Foxp3+ TregHeme oxygenase-1MAPKScrotal heat stress

Identifiers

PMID37086299
OpenAlexW4366742650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.