ReviewMolecular genetics and genomics : MGG2023
Role of circular RNAs in osteoarthritis: update on pathogenesis and therapeutics.
Review in Molecular genetics and genomics : MGG, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 6 citations in OpenAlex.
- Association Between Depressive Symptoms and Pain Intensity in Patients With Arthritis.Brain and behavior · 2026Article
- Circular RNAs coordinate immunomodulation in osteoarthritic cartilage via antigen presentation and adaptive immune response.BMC musculoskeletal disorders · 2026Article
- CircRNA HIPK2-mediated metabolic reprogramming restores mitochondrial homeostasis in chondrocytes through the miR-206/Sirt3 signaling axis attenuating osteoarthritis-induced nociception.Inflammopharmacology · 2026Article
- Research advancements on the role of CircRNAs in cartilage injury within osteoarthritis.Frontiers in genetics · 2026Review
- cZFP609 Tethering BiP Alleviates Cartilage Degradation in Osteoarthritis via Remedying Aberrant ER-Mitochondrial Contacts.MedComm · 2025Article
- CircTBCK protects against osteoarthritis by regulating extracellular matrix and autophagy.Human cell · 2025Article
- The emerging role of lncRNAs in osteoarthritis development and potential therapy.Frontiers in genetics · 2023Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA) is a common and crippling joint disease characterized by cartilage degeneration, subchondral bone sclerosis, and synovitis. The main clinical manifestations of OA are chronic joint pain and impaired mobility, which seriously affect patient's quality of life. Circular RNAs (circRNAs) are noncoding RNAs that are widely discovered in eukaryotic cells. Unlike standard linear RNAs, circRNAs form a covalently closed continuous loop structure without a 5' or 3' polarity. Various experiments in recent years have confirmed that numerous circRNAs appear to be differentially expressed in OA cartilage and synovium. And they are closely associated with various pathological progressions in OA, such as extracellular matrix degradation, chondrocyte apoptosis, and inflammation. In this review, we briefly described the biogenesis, characterization, and functions of circRNAs. And we focused on the relationships between circRNAs and OA progression. At last, we further discussed the prospects of clinical applications of circRNAs in OA, with the expectation to provide feasible directions for OA diagnosis and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.