Evidence map›Paper›PMID 37086000›Full record

Trial reportBrain and behavior2023

Sevoflurane and desflurane effects on early cognitive function after low-risk surgery: A randomized clinical trial.

Vilma Kuzminskaite, Egle Kontrimaviciute, Evaldas Kauzonas, Ieva Slauzgalvyte, Greta Bukelyte, Greta Bruzyte-Narkiene, Dalius Jatuzis

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vilma KuzminskaiteFaculty of Medicine, Clinic of Anesthesiology and Intensive Care, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania.ORCID 0000-0003-2253-9691
Egle KontrimaviciuteFaculty of Medicine, Clinic of Anesthesiology and Intensive Care, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania.
Evaldas KauzonasFaculty of Medicine, Vilnius University, Vilnius, Lithuania.
Ieva SlauzgalvyteFaculty of Medicine, Vilnius University, Vilnius, Lithuania.
Greta BukelyteFaculty of Medicine, Vilnius University, Vilnius, Lithuania.
Greta Bruzyte-NarkieneFaculty of Medicine, Vilnius University, Vilnius, Lithuania.
Dalius JatuzisFaculty of Medicine, Clinic of Neurology and Neurosurgery, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesDeleterious effects on short-term and long-term quality of life have been associated with the development of postoperative cognitive dysfunction (POCD) after general anesthesia. Yet, the progress in the field is still required. Most of the studies investigate POCD after major surgery, so scarce evidence exists about the incidence and effect different anesthetics have on POCD development after minor procedures. In this study, we compared early postoperative cognitive function of the sevoflurane and desflurane patients who experienced a low-risk surgery of thyroid gland. MATERIALS AND

methodsEighty-two patients, 40 years and over, with no previous severe cognitive, neurological, or psychiatric disorders, appointed for thyroid surgery under general anesthesia, were included in the study. In a random manner, the patients were allocated to either sevoflurane or desflurane study arms. Cognitive tests assessing memory, attention, and logical reasoning were performed twice: the day before the surgery and 24 h after the procedure. Primary outcome, magnitude of change in cognitive testing, results from baseline. POCD was diagnosed if postoperative score decreased by at least 20%.

resultsMedian change from baseline cognitive results did not differ between the sevoflurane and desflurane groups (-2.63%, IQR 19.3 vs. 1.13%, IQR 11.0; p = .222). POCD was detected in one patient (1.22%) of the sevoflurane group. Age, duration of anesthesia, postoperative pain, or patient satisfaction did not correlate with test scores. Intraoperative temperature negatively correlated with total postoperative score (r = -0.35, p = .007).

conclusionsBoth volatile agents proved to be equivalent in terms of the early cognitive functioning after low-risk thyroid surgery. Intraoperative body temperature may influence postoperative cognitive performance.

Indexed as

Anesthetics, InhalationIsofluraneMethyl EthersPostoperative Cognitive ComplicationsCognitionDesfluraneHumansQuality of LifeSevofluraneAnesthetics, InhalationDesfluraneIsofluraneMethyl EthersSevofluraneanesthesiadesfluranepostoperative cognitive dysfunctionsevoflurane

Identifiers

PMID37086000
PMCPMC10275520

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.