ArticleMolecular autism2023
Genetic and environmental contributions to co-occurring physical health conditions in autism spectrum condition and attention-deficit/hyperactivity disorder.
Article in Molecular autism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 17 citations in OpenAlex.
- Physical illnesses, mental or neurodevelopmental disorders, and multimorbidity in children: results from the Canadian Health Survey on Children and Youth.Social psychiatry and psychiatric epidemiology · 2026Article
- Mental health multimorbidity and physical conditions in children aged 6-17 years in the United States.General psychiatry · 2026Article
- Maternal health and autism risk: parsing direct and indirect genetic effects using 3-generation family linkage.medRxiv : the preprint server for health sciences · 2026Article
- Risk of hospitalization and death among autistic young people in England during the Covid-19 pandemic.Molecular autism · 2026Article
- [Research progress on mechanisms and clinical management of comorbid constipation in children with autism spectrum disorder].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Review
- Expanded Newborn Screening for Inborn Errors of Metabolism at a Single Center in Louisiana (2005-2024): Outcomes.International journal of neonatal screening · 2025Article
- Resilience in neurodivergence: professional perspectives mapped to the World Health Organisations' International Classification of Functioning.Scientific reports · 2025Article
- A qualitative study of risk and resilience for positive life outcomes in neurodivergence using the WHO ICF.Scientific reports · 2025Article
- Article
- Neuronal Populations Involved in Motor Function Show Prominent Expression of Sbno1 During Postnatal Brain Development.Journal of developmental biology · 2025Article
- Improved executive function and sleep quality in preteens with high-functioning autism following a structured physical activity program.Frontiers in psychiatry · 2025Article
- Communication issues in co-occurring ADHD and autism spectrum disorders. Evaluative approaches and targeted interventions: mini review.Postepy psychiatrii neurologii · 2024Review
- Review
- Clarifying the relationship and analyzing the influential factors of bronchial asthma in children with attention-deficit hyperactivity disorder.World journal of psychiatry · 2024Article
- Role of gastrointestinal health in managing children with autism spectrum disorder.World journal of clinical pediatrics · 2023Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutism spectrum condition and attention-deficit/hyperactivity disorder (ADHD) are associated with a range of physical health conditions. The aim of this study was to examine the etiological components contributing to co-occurring physical health conditions in autism and ADHD.
methodsIn this nationwide Child and Adolescent Twin Study in Sweden, we analyzed data from 10,347 twin pairs aged 9 and 12. Clinical diagnoses of autism, ADHD, and physical health conditions were identified through the Swedish National Patient Register. Subclinical phenotypes of autism and ADHD were defined by symptom thresholds on a standardized parent-interview, the Autism-Tics, ADHD, and Other Comorbidities inventory. Associations between physical health conditions and autism/ADHD phenotypes were examined using generalized estimating equations. Bivariate twin models were applied to estimate the extent to which genetic and environmental risk factors accounted for physical health comorbidities.
resultsSimilar patterns of association with physical health conditions were found in clinical and subclinical autism/ADHD, with odds ratios ranging from 1.31 for asthma in subclinical ADHD to 8.03 for epilepsy in clinical autism. The estimated genetic correlation (r LIMITATIONS: Importantly, since medical records from primary care were not included in the registry data used, we probably identified only more severe rather than the full range of physical health conditions. Furthermore, it needs to be considered that the higher prevalence of physical health conditions among autistic children and children with ADHD could be associated with the increased number of medical visits.
conclusionsShared genetic effects contribute significantly to autism and ADHD phenotypes with the co-occurring physical health conditions across different organ systems, including epilepsy and gastrointestinal disorders. The shared genetic liability with co-occurring physical health conditions was present across different levels of autism and ADHD symptom severity.
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