ArticleBMC psychiatry2023
Abnormal functional connectivity of the nucleus accumbens subregions mediates the association between anhedonia and major depressive disorder.
Article in BMC psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Abnormal resting-state functional connectivity in anhedonia: A systematic review and meta-analysis.Brain imaging and behavior · 2026Pooled it
- Functional and effective connectivity disruptions of the dopaminergic reward circuit in multiple sclerosis patients with depression.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- Reward pursuit during a translational reward task correlates with anhedonia reductions following rTMS in patients with major depressive disorder.Translational psychiatry · 2026Article
- Temporal Interference Electrical Stimulation for Neuropsychiatric Disorders: Mechanisms, Applications, and Translational Perspectives.International journal of molecular sciences · 2026Review
- Raphe subregion seeds reveal whole-brain functional connectivity differences underlying adolescent depression.BMC psychiatry · 2026Article
- Chronic Pain and Opioids in the Elderly: Treating the Brain, Not Just the Body.International journal of environmental research and public health · 2026Review
- Temporal dynamic changes in functional connectivity of reward network in depressed adolescents and young adults with and without suicidal attempts.BMC psychiatry · 2025Article
- Interaction of early life stress and NAD + /SIRT1 pathway genetic risk promotes depression.Translational psychiatry · 2025Article
- Neural effect of childhood maltreatment on neurovascular coupling in adolescent depression.European child & adolescent psychiatry · 2025Article
- Individualized functional brain mapping machine learning prediction of symptom-change resulting from selective kappa-opioid antagonism in an anhedonic sample from a Fast-Fail trial.Journal of mood and anxiety disorders · 2025Article
- Perturbing whole-brain models of brain hierarchy: An application for depression following pharmacological treatment.Annals of the New York Academy of Sciences · 2025Article
- Brain functional connectivity changes in amyotrophic lateral sclerosis with apathy and depression.Journal of neurology · 2025Article
- Reduced Functional Connectivity in Nucleus Accumbens Subregions Associates With Cognitive Changes in Alzheimer's Disease.Brain and behavior · 2025Article
- The Algorithmic Agent Perspective and Computational Neuropsychiatry: From Etiology to Advanced Therapy in Major Depressive Disorder.Entropy (Basel, Switzerland) · 2024Article
- Altered dynamic functional connectivity of nucleus accumbens subregions in major depressive disorder: the interactive effect of childhood trauma and diagnosis.Social cognitive and affective neuroscience · 2024Article
- Astrocyte-derived dominance winning reverses chronic stress-induced depressive behaviors.Molecular brain · 2024Article
- Neural substrates of predicting anhedonia symptoms in major depressive disorder via connectome-based modeling.CNS neuroscience & therapeutics · 2024Article
- Behavioral Activation and Brain Network Changes in Depression.Journal of clinical neurology (Seoul, Korea) · 2024Review
- Disrupted Resting-State Functional Connectivity and Effective Connectivity of the Nucleus Accumbens in Chronic Low Back Pain: A Cross-Sectional Study.Journal of pain research · 2024Article
- [Abnormal functional connectivity and structure-function coupling of the nucleus accumbens in patients with major depressive disorder].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe nucleus accumbens (Nac) is a crucial brain region in the pathophysiology of major depressive disorder (MDD) patients with anhedonia. However, the relationship between the functional imaging characteristics of Nac subregions and anhedonia remains unclear. Thus, this study aimed to investigate the role of resting-state functional connectivity (rsFC) of the Nac subregions between MDD and anhedonia.
methodsWe performed resting-state functional magnetic resonance imaging (fMRI) to measure the rsFC of Nac subregions in 55 MDD patients and 30 healthy controls (HCs). A two-sample t test was performed to determine the brain regions with varying rsFC among Nac subregions between groups. Then, correlation analyses were carried out to investigate the relationships between the aberrant rsFC of Nac subregions and the severity of anhedonia. Furthermore, we constructed a mediation model to explain the role of the aberrant rsFC of Nac subregions between MDD and the severity of anhedonia.
resultsCompared with the HC group, decreased rsFC of Nac subregions with regions of the prefrontal cortex, insula, lingual gyrus, and visual association cortex was observed in MDD patients. In the MDD group, the rsFC of the right Nac shell-like subregions with the middle frontal gyrus (MFG)/superior frontal gyrus (SFG) was correlated with consummatory anhedonia, and the rsFC of the Nac core-like subdivisions with the inferior frontal gyrus (IFG)/insula and lingual gyrus/visual association cortex was correlated with anticipatory anhedonia. More importantly, the functional alterations in the Nac subregions mediated the association between anhedonia and depression.
conclusionsThe present findings suggest that the functional alteration of the Nac subregions mediates the association between MDD and anhedonia, which provides evidence for the hypothesis that MDD patients have neurobiological underpinnings of reward systems that differ from those of HCs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.