Evidence map›Paper›PMID 37085737›Full record

ArticleMolecular diversity2024

Conjugates of ibuprofen inhibit CHIKV infection and inflammation.

Rudra N Dash, Mamidi Prabhudutta, Saikat De, Ranjit P Swain, Alok K Moharana, Bharat B Subudhi, Soma Chattopadhyay

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Network Pharmacology, Molecular Docking andCurrent computer-aided drug design · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rudra N DashDrug Development and Analysis Laboratory, School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Kalinga Nagar, Bhubaneswar, 751003, Odisha, India.
Mamidi PrabhuduttaInfectious Disease Biology Lab, Institute of Life Sciences, Bhubaneswar, 751023, Odisha, India.
Saikat DeInfectious Disease Biology Lab, Institute of Life Sciences, Bhubaneswar, 751023, Odisha, India.
Ranjit P SwainDrug Development and Analysis Laboratory, School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Kalinga Nagar, Bhubaneswar, 751003, Odisha, India.
Alok K MoharanaDrug Development and Analysis Laboratory, School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Kalinga Nagar, Bhubaneswar, 751003, Odisha, India.
Bharat B SubudhiDrug Development and Analysis Laboratory, School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Kalinga Nagar, Bhubaneswar, 751003, Odisha, India. bharatbhusans@gmail.com.
Soma ChattopadhyayInfectious Disease Biology Lab, Institute of Life Sciences, Bhubaneswar, 751023, Odisha, India. sochat.ils@gmail.com.
Siksha O Anusandhan University · INAll India Institute of Medical Sciences Bhubaneswar · INRegional Centre for Biotechnology · IN

Funding

Science and Engineering Research Board EMR/2015/002433
6 · The paper itself

Abstract

Chikungunya virus infection has become a global health concern because of its high rates of morbidity and mortality in patients with preexisting conditions. Inflammation and arthritis are the major symptoms of CHIKV that persist even after clearance of CHIKV. To develop an antiviral that can reduce infection and manage inflammation independent of the CHIKV infection, ibuprofen (IBU) conjugates with sulfonamide and thiosemicarbazide were synthesized. The conjugates, IBU-SULFA, IBU-ISS and IBU-IBT significantly inhibited CHIKV infection in vitro with a selectivity index (CC

Indexed as

Antiviral AgentsChikungunya FeverChikungunya virusIbuprofenInflammationAnimalsArthritisChlorocebus aethiopsHumansRatsSemicarbazidesSulfonamidesVero CellsAntiviral AgentsIbuprofenSemicarbazidesSulfonamidesthiosemicarbazideAntiviralArthritisChikungunya virusIbuprofenSulfonamideThiosemicarbazide

Identifiers

PMID37085737
OpenAlexW4366679832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.