ArticleCommunications biology2023
Lunar gravity prevents skeletal muscle atrophy but not myofiber type shift in mice.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
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- ibSLS as a biobank for democratizing access to multi-omics data and biospecimens from spaceflight research.Nature communications · 2026Article
- Spaceflight and the rodent skeleton: A perspective.Bone reports · 2026Review
- Achilles tendon exhibits distinct transcriptomic changes with increased mitochondrial energy production under lunar gravity.NPJ microgravity · 2026Article
- Estrogen Receptor Alpha (ERα) Is Involved in Resveratrol-Mediated Muscle Preservation During Mechanical Unloading in Male Rats.Muscles (Basel, Switzerland) · 2026Article
- 0.33Science advances · 2026Article
- Integrated cross-species translation and biophysical multi-scale modeling links molecular signatures and locomotory phenotypes in spaceflight-induced sarcopenia.NPJ microgravity · 2026Article
- Cell biomechanics on muscle atrophy: from intricate mechanisms to therapeutic frontiers.Annals of medicine · 2025Review
- Lunar life drives jawbone formation.Journal of dental sciences · 2025Article
- Simulated microgravity accurately models long-duration spaceflight effects on bone and skeletal muscle in skeletally immature mice.Bone reports · 2025Article
- Large MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle.Skeletal muscle · 2025Article
- Oxidative Damage Under Microgravity Conditions: Response Mechanisms, Monitoring Methods and Countermeasures on Somatic and Germ Cells.International journal of molecular sciences · 2025Review
- Impact of microgravity and lunar gravity on murine skeletal and immune systems during space travel.Scientific reports · 2024Article
- CRISPR Screen Identifies the RNA-Binding Protein Eef1a1 as a Key Regulator of Myogenesis.International journal of molecular sciences · 2024Article
- Simulated microgravity attenuates myogenesis and contractile function of 3D engineered skeletal muscle tissues.NPJ microgravity · 2024Article
- Upregulation ofFrontiers in physiology · 2024Article
Corrections and comments
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Authors and funding
24 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal muscle is sensitive to gravitational alterations. We recently developed a multiple artificial-gravity research system (MARS), which can generate gravity ranging from microgravity to Earth gravity (1 g) in space. Using the MARS, we studied the effects of three different gravitational levels (microgravity, lunar gravity [1/6 g], and 1 g) on the skeletal muscle mass and myofiber constitution in mice. All mice survived and returned to Earth, and skeletal muscle was collected two days after landing. We observed that microgravity-induced soleus muscle atrophy was prevented by lunar gravity. However, lunar gravity failed to prevent the slow-to-fast myofiber transition in the soleus muscle in space. These results suggest that lunar gravity is enough to maintain proteostasis, but a greater gravitational force is required to prevent the myofiber type transition. Our study proposes that different gravitational thresholds may be required for skeletal muscle adaptation.
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