Evidence map›Paper›PMID 37085695›Full record

ArticleScientific reports2023

Associating broad and clinically defined polygenic scores for depression with depression-related phenotypes.

John E McGeary, Chelsie E Benca-Bachman, Victoria A Risner, Christopher G Beevers, Brandon E Gibb, Rohan H C Palmer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

John E McGeary *Providence Veterans Affairs Medical Center, Providence, RI, USA.ORCID 0000-0003-4025-9511
Chelsie E Benca-Bachman *Providence Veterans Affairs Medical Center, Providence, RI, USA. chelsie.benca@emory.edu.ORCID 0000-0002-5372-4593
Victoria A RisnerBehavioral Genetics of Addiction Laboratory, Department of Psychology, Emory University, 36 Eagle Row, Atlanta, GA, 30322, USA.ORCID 0000-0002-3543-8147
Christopher G BeeversDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-4480-0902
Brandon E GibbDepartment of Psychology State, University of New York at Binghamton, Binghamton, NY, USA.ORCID 0000-0002-9482-067X
Rohan H C PalmerProvidence Veterans Affairs Medical Center, Providence, RI, USA.ORCID 0000-0002-6809-9962

Funding

Integrative Prioritization of Alcohol and Drug-Addiction Related Genetic LociR01DA042742 · NIDA · EMORY UNIVERSITY · PI PALMER, ROHAN HUGH CRAIG · 2018 to 2022
$1.7M
Advancing the Research Careers of Women and PEERs in Brain ScienceR25NS124530 · NINDS · BROWN UNIVERSITY · PI CARLOS D AIZENMAN, Diane Lipscombe · 2022 to 2026
$1.3M
Contribution of Genome-Wide Variation to Cognitive Vulnerability to DepressionR56MH108650 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI ALLEN, JOHN J., BEEVERS, CHRISTOPHER G · 2016 to 2016
$767k
Brown University Shared DNA SequencerS10RR023457 · NCRR · BROWN UNIVERSITY · PI MCGEARY, JOHN E · 2008 to 2008
$147k
NCRR NIH HHS S10 RR023457NIDA NIH HHS R01 DA042742NIMH NIH HHS R56 MH108650NINDS NIH HHS R25 NS124530
6 · The paper itself

Abstract

Twin studies indicate that 30-40% of the disease liability for depression can be attributed to genetic differences. Here, we assess the explanatory ability of polygenic scores (PGS) based on broad- (PGS

Indexed as

AnhedoniaDepressionGenome-Wide Association StudyHumansMultifactorial InheritancePhenotypeSuicidal Ideation

Identifiers

PMID37085695
PMCPMC10121555

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.