Evidence map›Paper›PMID 37085595›Full record

ArticleScientific reports2023

Influenza season influence on outcome of new nodules in the NELSON study.

H L Lancaster, M A Heuvelmans, G H de Bock, Y Du, F A A Mohamed Hoesein, K Nackaerts, J E Walter, R Vliegenthart, M Oudkerk

Abstract read
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In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

H L LancasterDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
M A HeuvelmansDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
G H de BockDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Y DuDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
F A A Mohamed HoeseinDepartment of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
K NackaertsDepartment of Pneumology, University Hospital Leuven, KU Leuven, Leuven, Belgium.
J E WalterDepartment of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland.
R VliegenthartDepartment of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
M OudkerkFaculty of Medical Sciences, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands. m.oudkerk@rug.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated the impact of the influenza season on outcome of new lung nodules in a LDCT lung cancer screening trial population. NELSON-trial participants with ≥ 1 new nodule detected in screening rounds two and three were included. Outcome (resolution or persistence) of new nodules detected per season was calculated and compared. Winter (influenza season) was defined as 1st October to 31st March, and compared to the summer (hay-fever season), 1st April to 30th September. Overall, 820 new nodules were reported in 529 participants. Of the total new nodules, 482 (59%) were reported during winter. When considering the outcome of all new nodules, there was no statistically significant association between summer and resolving nodules (OR 1.07 [CI 1.00-1.15], p = 0.066), also when looking at the largest nodule per participant (OR 1.37 [CI 0.95-1.98], p = 0.094). Similarly, there was no statistically significant association between season and screen detected cancers (OR 0.47 [CI 0.18-1.23], p = 0.123). To conclude, in this lung cancer screening population, there was no statistically significant association between influenza season and outcome of new lung nodules. Hence, we recommend new nodule management strategy is not influenced by the season in which the nodule is detected.

Indexed as

Influenza, HumanLung NeoplasmsMultiple Pulmonary NodulesSolitary Pulmonary NoduleEarly Detection of CancerHumansSeasonsTomography, X-Ray Computed

Identifiers

PMID37085595
PMCPMC10121576

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.