ArticleScientific reports2023
Clinical and microbiological characteristics of bloodstream infection caused by Klebsiella pneumoniae harboring rmpA in Japanese adults.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Emerging hypervirulent and extensively drug-resistant Klebsiella pneumoniae with potent biofilm formation as a new clinical challenge.Molecular biology reports · 2026Article
- HypervirulentMicrobiology spectrum · 2026Article
- Polydextrose reduces the infection ofMicrobiology spectrum · 2025Article
- Unraveling ESBL and AmpC resistance in multi-drug resistant Klebsiella pneumoniae: phenotypic and genotypic insights.Molecular biology reports · 2025Article
- The Brief Case: A renal abscess caused by ST35-KL108, a strain of multidrug-resistant hypervirulentJournal of clinical microbiology · 2025Review
- Beyond the abscess:Frontiers in cellular and infection microbiology · 2025Article
- Detection of Hypervirulence Genes and Drug Resistance inScientifica · 2025Article
- Antibiotic resistance and virulence profile ofJournal of advanced veterinary and animal research · 2024Article
- Epidemiological and Molecular Characteristics of Hypermucoviscous and HypervirulentInfection and drug resistance · 2024Article
- Molecular and phenotypic characterization ofFrontiers in cellular and infection microbiology · 2024Article
- Extensive Expression of the Virulome Related to Antibiotic Genotyping in Nosocomial Strains ofInternational journal of molecular sciences · 2023Article
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9 authors.
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Abstract
We investigated the clinical features of bloodstream infections (BSIs) caused by Klebsiella pneumoniae harboring rmpA and molecular characteristics of the bacteria. We retrospectively investigated adult patients with K. pneumoniae BSI from January 2010 to March 2021 at Nagasaki University Hospital. A matched case-control study in a 1:3 ratio was conducted to clarify the clinical and bacterial characteristics of BSI caused by rmpA-positive K. pneumoniae compared with those caused by rmpA-negative isolates. Antimicrobial susceptibility testing and multilocus sequence typing (MLST) were performed for rmpA-positive isolates. The rmpA was detected in 36 (13.4%) of the 268 isolates. Of these 36 isolates, 31 (86.1%) harbored iucA and 35 (97.2%) each possessed peg-344 and iroB; capsular types were identified as K1 in 9 (25.0%) and K2 in 10 isolates (27.8%). Contrarily, of the 108 rmpA-negative isolates, which were matched for case-control studies, 5 isolates (4.6%) harbored iucA and 1 (0.9%) each possessed peg-344 and iroB; 2 (1.9%) and 3 isolates (2.8%) had K1 and K2 capsular types, respectively. Among the rmpA-positive isolates, ST23/K1 (eight isolates) was the most frequent, followed by ST412/non-K1/K2 (seven isolates), ST86/K2 (five isolates), and ST268/non-K1/K2 (four isolates). In a multivariate analysis using clinical factors, liver abscess positively correlated with rmpA-positive isolates, whereas biliary tract infection and use of anticancer drugs negatively correlated with rmpA-positive isolates in patients with K. pneumoniae BSI. Considering the correlation between rmpA-positive isolates and clinical features, rmpA can be used as a marker for understanding the pathophysiology of K. pneumoniae BSI.
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