ReviewNature communications2023
Microbial biomanufacturing for space-exploration-what to take and when to make.
Review in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Electroporation outcomes in human Jurkat cells are affected by exposure to simulated microgravity.Research square · 2026Article
- Collagen-heparan sulfate microcarriers support mesenchymal stem cell culture in microgravity and streamline post-flight recovery.NPJ microgravity · 2026Article
- Influence of gravity variations on the activity of neuronal spheroids in an acoustic trap.NPJ microgravity · 2026Article
- Effects of Microbial Fertilizers on the Properties of Simulated Lunar Soil and Lettuce Growth.Plants (Basel, Switzerland) · 2026Article
- Orbital biomanufacturing: the key to space resiliency, operational persistence, and ethical sustainability.NPJ microgravity · 2026Review
- Yeast-driven biomanufacturing in space: synergizing cellular agriculture for sustainable extraterrestrial habitats.NPJ microgravity · 2026Review
- Anabaena-a promising chassis for space exploration.NPJ microgravity · 2026Review
- Microbial biomining from asteroidal material onboard the international space station.NPJ microgravity · 2026Article
- Microgravity-induced constraints on melanin bioproduction: investigating E. coli metabolic responses aboard the international space station.NPJ microgravity · 2026Article
- Emerging Chemical and Biological Materials Technologies in the Extraplanetary Environment.Nano-micro letters · 2026Review
- Streamlined molecular farming of plant virus therapeutics for space flight and other low-resource environments.NPJ science of plants · 2026Article
- Proteomics of long-term acclimation of the desert cyanobacteriumCurrent research in microbial sciences · 2026Article
- Review
- Integrating resource utilization and bioregenerative life support systems for sustainable space exploration.Frontiers in microbiology · 2026Review
- Cryogenic microcarrier-assisted stem cell storage (Cryo-MASCS): a preservation method enabling scalable culture of human mesenchymal stem cells.Stem cell research & therapy · 2025Article
- Isolation of bacteria that catabolize abiotically synthesized tetroses via the formose reaction.Scientific reports · 2025Article
- Cathodic Hydroxide Ions Induce Tetrose Formation during Glycolaldehyde Electroreduction to Alcohols: A Potential COAngewandte Chemie (International ed. in English) · 2025Article
- Developing an alternative medium for in-space biomanufacturing.Nature communications · 2025Article
- Evaluation of theFrontiers in bioengineering and biotechnology · 2025Article
- Pharmacological Innovations in Space: Challenges and Future Perspectives.Pharmaceutical research · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As renewed interest in human space-exploration intensifies, a coherent and modernized strategy for mission design and planning has become increasingly crucial. Biotechnology has emerged as a promising approach to increase resilience, flexibility, and efficiency of missions, by virtue of its ability to effectively utilize in situ resources and reclaim resources from waste streams. Here we outline four primary mission-classes on Moon and Mars that drive a staged and accretive biomanufacturing strategy. Each class requires a unique approach to integrate biomanufacturing into the existing mission-architecture and so faces unique challenges in technology development. These challenges stem directly from the resources available in a given mission-class-the degree to which feedstocks are derived from cargo and in situ resources-and the degree to which loop-closure is necessary. As mission duration and distance from Earth increase, the benefits of specialized, sustainable biomanufacturing processes also increase. Consequentially, we define specific design-scenarios and quantify the usefulness of in-space biomanufacturing, to guide techno-economics of space-missions. Especially materials emerged as a potentially pivotal target for biomanufacturing with large impact on up-mass cost. Subsequently, we outline the processes needed for development, testing, and deployment of requisite technologies. As space-related technology development often does, these advancements are likely to have profound implications for the creation of a resilient circular bioeconomy on Earth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.