Observational studyReproductive biomedicine online2023
Perceived stress and markers of ovarian reserve among subfertile women.
Observational study in Reproductive biomedicine online, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Cortisol-to-cortisone ratio postpartum is associated with anti-Müllerian hormone a decade later: evidence from a prospective study.Endocrine connections · 2026Article
- Associations Between Reproductive Disorders and Specific Physical, Mental, Personality, and Social Characteristics: A Narrative Review.Health science reports · 2026Article
- Recent advances in methods for establishing animal models of premature ovarian failure.Journal of ovarian research · 2025Review
- [Diagnostic value of the blood steroid profile in secondary amenorrhea].Problemy endokrinologii · 2025Article
- Perceived stress in relation to testicular function markers among men attending a fertility center.Fertility and sterility · 2025Observational
- Neighborhood Vulnerability and Age of Natural Menopause and Menopausal Symptoms Among Midlife Women.JAMA network open · 2025Article
- Impact of psychological stress on ovarian function: Insights, mechanisms and intervention strategies (Review).International journal of molecular medicine · 2025Review
- The effect of environmental stressors on anti-mullerian hormone levels in Lebanese women: a retrospective study.PloS one · 2025Article
- An extra X chromosome among adult women in the Million Veteran Program: A more benign perspective of trisomy X.American journal of medical genetics. Part C, Seminars in medical genetics · 2024Article
- Psychological Morbidity (Stress, Anxiety and Depression) and Fertility Quality of Life amongst Infertile Women with and without Polycystic Ovary Syndrome (PCOS): A Cross-sectional Study.Journal of human reproductive sciencesArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
research questionIs self-reported psychological stress associated with markers of ovarian reserve among subfertile women?
designObservational study of women (n = 520) seeking fertility care at the Massachusetts General Hospital who enrolled in the Environment and Reproductive Health study between 2005 and 2019. Women completed the short version of the validated PSS4, which assesses psychological stress. Ovarian reserve markers included AFC and circulating serum levels of day-3 FSH, with AMH assessed in a subset of participants (n = 185).
resultsHigher total PSS4 scores were negatively associated with AFC and serum AMH levels. Analyses adjusted for age, BMI, race, smoking, education, physical activity and type of infertility diagnosis. Women in the second and third tertiles of stress had lower AFC (13.3, 95% CI 12.7 to 13.8; and 13.5, 95% CI 13.0 to 14.1) compared with women in the lowest tertile of psychological stress score (14.3, 95% CI 13.8 to 14.9, both P < 0.05). Women in the second and third tertiles of total PSS4 scores also had lower mean serum AMH compared with women in the lowest tertile (2.99, 95% CI 2.24 to 3.74), and (2.99 95% CI 2.22 to 3.76) versus (3.94 95% CI 3.23 to 4.64). These associations varied by several socioeconomic factors, and were observed among women who were younger, belonging to minority races, with a college degree or with annual household income less than $100,000.
conclusionsHigher perceived stress was negatively associated with AFC and serum AMH levels. These associations varied by several socioeconomic factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.