Evidence map›Paper›PMID 37085283›Full record

Observational studyBMJ open respiratory research2023

Impact of prophylactic and 'rescue pack' antibiotics on the airway microbiome in chronic lung disease.

Sylvia A D Rofael, James Brown, Marc C I Lipman, David M Lowe, David Spratt, Shumonta Quaderi, John R Hurst, Timothy D McHugh

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open respiratory research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Infection and the microbiome in bronchiectasis.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Sylvia A D RofaelUCL Centre for Clinical Microbiology, Division of Infection & Immunity, University College London, London, UK.
James BrownUCL Respiratory, Divison of Medicine, University College London, London, UK.
Marc C I LipmanUCL Respiratory, Divison of Medicine, University College London, London, UK.
David M LoweInstitute for Immunity and Transplantation, Divison of Infection and Immunity, University College London, London, UK.
David SprattDepartment of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK.
Shumonta QuaderiUCL Respiratory, Divison of Medicine, University College London, London, UK.
John R HurstUCL Respiratory, Divison of Medicine, University College London, London, UK.
Timothy D McHughUCL Centre for Clinical Microbiology, Division of Infection & Immunity, University College London, London, UK t.mchugh@ucl.ac.uk.
University College London · GBLondon Chest Hospital · GBAlexandria University · EGRespiratory Clinical Trials · AURoyal Free London NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The management of many chronic lung diseases involves multiple antibiotic prescriptions either to treat acute exacerbations or as prophylactic therapy to reduce the frequency of exacerbations and improve patients' quality of life.

aimTo investigate the effects of antibiotics on the homeostasis of bacterial communities in the airways, and how this may contribute to antimicrobial resistance (AMR) among respiratory pathogens and microbiota.

methodsWithin an observational cohort study, sputum was collected from 84 patients with chronic obstructive pulmonary disease and/or bronchiectasis at stable state: 47 were receiving antibiotic prophylaxis therapy. V3-V4 16S-rRNA sequencing on Illumina MiSeq, quantitative PCR for typical respiratory pathogens, bacteriology cultures and antimicrobial susceptibility testing of sputum isolates, resistome analysis on a subset of 17 sputum samples using MinION metagenomics sequencing were performed. FINDING: The phylogenetic α-diversity and the total bacterial density in sputum were significantly lower in patients receiving prophylactic antibiotics (p=0.014 and 0.029, respectively). Antibiotic prophylaxis was associated with significantly lower relative abundance of respiratory pathogens such as

conclusionsAntibiotic prophylactic therapy suppresses recognised pathogenic bacteria in the sputum of patients with chronic lung disease. The use of antibiotic rescue packs may be driving AMR in this cohort rather than prophylactic antibiotics.

Indexed as

MicrobiotaPulmonary Disease, Chronic ObstructiveAnti-Bacterial AgentsHumansPhylogenyQuality of LifeAnti-Bacterial Agentsbacterial infectionbronchiectasisCOPD exacerbationsrespiratory infection

Identifiers

PMID37085283
PMCPMC10124267
OpenAlexW4366742496

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.