Evidence map›Paper›PMID 37085072›Full record

ArticleInternational journal of biological macromolecules2023

Effect of proteins isolated from Brazilian snakes on enterovirus A71 replication cycle: An approach against hand, foot and mouth disease.

Jacqueline Farinha Shimizu, Shiraz Feferbaum-Leite, Igor Andrade Santos, Daniel Oliveira Silva Martins, Natalie J Kingston, Mona Shegdar, Carsten Zothner, Suely Vilela Sampaio, Mark Harris, Nicola J Stonehouse and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological macromolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jacqueline Farinha ShimizuLaboratory of Antiviral Research, Institute of Biomedical Science - ICBIM, Federal University of Uberlândia - UFU, Uberlândia, MG, Brazil; Institute of Biosciences, Language and Exact Science - IBILCE, São Paulo State University - UNESP, São José do Rio Preto, SP, Brazil; Brazilian Biosciences National Laboratory (LNBio), Brazilian Centre for Research in Energy and Materials (CNPEM), Campinas, SP 13083-100, Brazil.
Shiraz Feferbaum-LeiteLaboratory of Antiviral Research, Institute of Biomedical Science - ICBIM, Federal University of Uberlândia - UFU, Uberlândia, MG, Brazil.
Igor Andrade SantosLaboratory of Antiviral Research, Institute of Biomedical Science - ICBIM, Federal University of Uberlândia - UFU, Uberlândia, MG, Brazil.
Daniel Oliveira Silva MartinsLaboratory of Antiviral Research, Institute of Biomedical Science - ICBIM, Federal University of Uberlândia - UFU, Uberlândia, MG, Brazil; Institute of Biosciences, Language and Exact Science - IBILCE, São Paulo State University - UNESP, São José do Rio Preto, SP, Brazil.
Natalie J KingstonSchool of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
Mona ShegdarSchool of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
Carsten ZothnerSchool of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
Suely Vilela SampaioDepartment of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - USP, SP, Brazil.
Mark HarrisSchool of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
Nicola J StonehouseSchool of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
Ana Carolina Gomes JardimLaboratory of Antiviral Research, Institute of Biomedical Science - ICBIM, Federal University of Uberlândia - UFU, Uberlândia, MG, Brazil; Institute of Biosciences, Language and Exact Science - IBILCE, São Paulo State University - UNESP, São José do Rio Preto, SP, Brazil. Electronic address: jardim@ufu.br.

Funding

Medical Research Council MR/P022626/1Medical Research Council MR/S001026/1Wellcome Trust 096670
6 · The paper itself

Abstract

Enterovirus A71 (EVA71) belongs to the Picornaviridae family and is the main etiological agent of hand, foot, and mouth disease (HFMD). There is no approved antiviral against EVA71, and therefore the search for novel anti-EVA71 therapeutics is essential. In this context, the antiviral activity of proteins isolated from snake venoms has been reported against a range of viruses. Here, the proteins CM10 and CM14 isolated from Bothrops moojeni, and Crotamin and PLA2

Indexed as

Crotalid VenomsEnterovirusEnterovirus InfectionsHand, Foot and Mouth DiseaseAnimalsAntigens, ViralAntiviral AgentsBrazilPhospholipases A2ProteinsSnakesAntigens, ViralAntiviral AgentsCrotalid VenomsPhospholipases A2ProteinsAntiviralBrazilian snakesEnterovirus A71EVA71Toxins

Identifiers

PMID37085072
PMCPMC7615699

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.