ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2023
Consensus guide on CT-based prediction of stopping-power ratio using a Hounsfield look-up table for proton therapy.
Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed.
- Impact of beam hardening on proton stopping-power ratio estimation using photon-counting, dual-energy, and single-energy computed tomography.Physics and imaging in radiation oncology · 2026Article
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- Comparison of three commercial multi-energy CT and electron density phantoms for iodine quantification and tissue substitute characterization.Journal of applied clinical medical physics · 2026Article
- A review on radiological properties of fused deposition modelling material for three-dimensional printing in proton and light ion beam therapy.Physics and imaging in radiation oncology · 2026Review
- Longitudinal CT number characterization of a novel upright CT for proton therapy planning.Journal of applied clinical medical physics · 2026Article
- Latent density discrepancies in commercial lung-equivalent inserts and their clinical dosimetric impact.Journal of applied clinical medical physics · 2026Article
- Reduction of CT number location dependency using photon-counting detector CT and virtual monoenergetic imaging.Physics in medicine and biology · 2026Article
- Case Report: Proton Therapy of a Pregnant Patient With Small-Cell Lung Cancer in the Third Trimester Using Synthetic Computed Tomographies for Tumor Monitoring.Advances in radiation oncology · 2026Article
- Assessing accuracy and artefacts in proton stopping power ratio images across four computed tomography imaging workflows using a head-sized electron density phantom.Radiation protection dosimetry · 2026Article
- Clinical commissioning of a novel compact multi-room pencil beam scanning proton therapy system.Journal of applied clinical medical physics · 2026Article
- Trends and Challenges: A 15-Year Review of Imaging and Radiation Oncology Core Anthropomorphic Phantom Audits for Proton Therapy.International journal of particle therapy · 2026Article
- Accuracy of Photon Dose Calculation on Photon-Counting Computed Tomography-A Comparison Study Based on Virtual Monoenergetic and Electron Density (Rho) Images for Pancreatic Cases.Advances in radiation oncology · 2026Article
- Article
- Photon-counting computed tomography for stopping power ratio prediction in proton therapy.Medical physics · 2025Article
- Practical considerations for handling implants in proton therapy.Journal of applied clinical medical physics · 2025Article
- Imaging, automation and workflow challenges for online adaptive proton therapy.Physics and imaging in radiation oncology · 2025Article
- Comparison of cone beam computed tomography post-processing methods for online adaptive proton therapy of prostate cancer.Physics and imaging in radiation oncology · 2025Article
- Comparison of two dual-energy CT-based methods for proton stopping-power ratio estimation in brain cancer patients with metal implants.Acta oncologica (Stockholm, Sweden) · 2025Article
- Combined single- and dual-energy CT workflow for dose calculation in radiotherapy.Acta oncologica (Stockholm, Sweden) · 2025Article
- Accuracy of a helium-beam radiography system based on thin pixel detectors for an anthropomorphic head phantom.Medical physics · 2025Article
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18 authors.
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Abstract
background and purposeStudies have shown large variations in stopping-power ratio (SPR) prediction from computed tomography (CT) across European proton centres. To standardise this process, a step-by-step guide on specifying a Hounsfield look-up table (HLUT) is presented here. MATERIALS AND
methodsThe HLUT specification process is divided into six steps: Phantom setup, CT acquisition, CT number extraction, SPR determination, HLUT specification, and HLUT validation. Appropriate CT phantoms have a head- and body-sized part, with tissue-equivalent inserts in regard to X-ray and proton interactions. CT numbers are extracted from a region-of-interest covering the inner 70% of each insert in-plane and several axial CT slices in scan direction. For optimal HLUT specification, the SPR of phantom inserts is measured in a proton beam and the SPR of tabulated human tissues is computed stoichiometrically at 100 MeV. Including both phantom inserts and tabulated human tissues increases HLUT stability. Piecewise linear regressions are performed between CT numbers and SPRs for four tissue groups (lung, adipose, soft tissue, and bone) and then connected with straight lines. Finally, a thorough but simple validation is performed.
resultsThe best practices and individual challenges are explained comprehensively for each step. A well-defined strategy for specifying the connection points between the individual line segments of the HLUT is presented. The guide was tested exemplarily on three CT scanners from different vendors, proving its feasibility.
conclusionThe presented step-by-step guide for CT-based HLUT specification with recommendations and examples can contribute to reduce inter-centre variations in SPR prediction.
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