Evidence map›Paper›PMID 37084814›Full record

ArticleThe American journal of clinical nutrition2023

Vitamin D Supplementation and Muscle Power, Strength and Physical Performance in Older Adults: A Randomized Controlled Trial.

Denise K Houston, Anthony P Marsh, Rebecca H Neiberg, Jamehl L Demons, Claudia L Campos, Stephen B Kritchevsky, Osvaldo Delbono, Janet A Tooze

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. Does 25(OH)D deficiency affect muscle elasticity, physical function, pain, and quality of life? A shear-wave elastography-based cross-sectional study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
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  8. mTOR-Gut Microbiome Interaction in Aging: Fusobacterium nucleatum, Resistance Training and Multi-nutrient Supplementation Effects in Aged Male Rats.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  9. [Interpretation of the Expert Consensus Statement on the Role of Vitamin D in Metabolic Health].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Article
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  11. 25-Hydroxyvitamin DScientific reports · 2026
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  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Denise K HoustonDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA. Electronic address: dhouston@wakehealth.edu.
Anthony P MarshDepartment of Health and Exercise Science, Wake Forest University, Winston Salem, NC, USA.
Rebecca H NeibergDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Jamehl L DemonsDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Claudia L CamposDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Stephen B KritchevskyDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Osvaldo DelbonoDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Janet A ToozeDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Wake Forest University · US

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
Trial of vitamin D supplementation and neuromuscular functioin in older adultsR01AG042411 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HOUSTON, DENISE KATHRYN · 2013 to 2017
$3.4M
NIA NIH HHS P30 AG021332NIA NIH HHS R01 AG042411
6 · The paper itself

Abstract

backgroundLow 25-hydroxyvitamin D (25[OH]D) concentrations (<30 ng/mL [<50 nmol/L]) have been associated with muscle weakness and impaired physical performance in observational studies. However, the effect of vitamin D supplementation on changes in muscle strength and physical performance in randomized controlled trials has been mixed.

objectivesTo determine the effect of daily vitamin D supplementation on leg power, strength, and physical performance in low-functioning older adults with 25(OH)D concentrations of 18 to <30 ng/mL.

methodsIn this double-blind, randomized controlled trial, 136 low-functioning [Short Physical Performance Battery (SPPB) scores ≤10] adults aged 65-89 y with 25(OH)D concentrations of 18 to <30 ng/mL were randomly assigned to 2000 IU/d vitamin D

resultsParticipants' mean ± SD age and SPPB scores at baseline were 73.4 ± 6.3 y and 7.8 ± 1.8, respectively. Mean ± SD 25(OH)D concentrations at baseline and 12 mo were 19.4 ± 4.2 ng/mL and 28.6 ± 6.7 ng/mL in the vitamin D group and 19.9 ± 4.9 ng/mL and 20.2 ± 5.0 ng/mL in the placebo group for a mean ± SE difference of 9.1 ± 1.1 ng/mL (P < 0.0001). However, there were no differences in change in leg power, leg or grip strength, SPPB score, TUG, postural sway, or gait velocity and spatiotemporal parameters by intervention group over 12 mo or muscle fiber composition and contractile properties over 4 mo.

conclusionsIn low-functioning older adults with 25(OH)D concentrations of 18 to <30 ng/mL, randomization to 2000 IU/d vitamin D

Indexed as

Dietary SupplementsVitamin D DeficiencyAgedCholecalciferolDouble-Blind MethodHumansMusclesMuscle StrengthPhysical Functional PerformanceRandomized Controlled Trials as TopicVitamin DVitaminsCholecalciferolVitamin DVitaminsleg powerolder adultsphysical performancestrengthvitamin D

Identifiers

PMID37084814
PMCPMC10447505
OpenAlexW4366393761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.