Evidence map›Paper›PMID 37084729›Full record

ReviewCell stem cell2023

Advancing cell therapy for neurodegenerative diseases.

Sally Temple

Open access · bronzeAbstract readReview
In one paragraph

Review in Cell stem cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 2 pooled it
26.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 2 syntheses or guidelines pooled it, 170 citations in OpenAlex.

  1. Pooled it
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  11. Temporal Interference Stimulation Enhances Neural Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Sally TempleNeural Stem Cell Institute, Rensselaer, NY 12144, USA. Electronic address: sallytemple@neuralsci.org.
Neural Stem Cell Institute · US

Funding

Investigating the Functional Impact of AD Risk Genes on Neuro-Vascular InteractionsU01AG072464 · NIA · REGENERATIVE RESEARCH FOUNDATION · PI HARARI, OSCAR, KAMPMANN, MARTIN · 2021 to 2025
$8.7M
Defining Characteristics of Cortical Progenitor Cells over Time in Mouse and HumanR35NS097277 · NINDS · REGENERATIVE RESEARCH FOUNDATION · PI TEMPLE, SALLY · 2017 to 2024
$5.0M
Characterizing Human RPE Cell Proliferation to Advance Endogenous RegenerationR01EY032138 · NEI · REGENERATIVE RESEARCH FOUNDATION · PI TEMPLE, SALLY · 2021 to 2024
$2.3M
Cell Type and Regional Vulnerability in Frontotemporal DementiaRF1NS123568 · NINDS · REGENERATIVE RESEARCH FOUNDATION · PI TEMPLE, SALLY · 2021 to 2021
$2.1M
NEI NIH HHS R01 EY032138NIA NIH HHS U01 AG072464NINDS NIH HHS R35 NS097277NINDS NIH HHS RF1 NS123568
6 · The paper itself

Abstract

Cell-based therapies are being developed for various neurodegenerative diseases that affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in neurodegenerative pathology are being uncovered by genetic and single-cell studies. With a greater understanding of cellular contributions to health and disease and with the arrival of promising approaches to modulate them, effective therapeutic cell products are now emerging. This review examines how the ability to generate diverse CNS cell types from stem cells, along with a deeper understanding of cell-type-specific functions and pathology, is advancing preclinical development of cell products for the treatment of neurodegenerative diseases.

Indexed as

Neurodegenerative DiseasesCell- and Tissue-Based TherapyCentral Nervous SystemHumansStem Cellsage-related macular degenerationAlzheimer diseaseastrocytescentral nervous systemdopaminergic neuronsfrontotemporal dementiaGABAergic neuronsmicroglianeurodegenerative diseaseneuronsoligodendrocytesorganoidsParkinson diseasephotoreceptorspreclinical studiesprogressive supranuclear palsyretinaretinal pigment epitheliumstem cell therapytransplantation

Identifiers

PMID37084729
PMCPMC10201979
OpenAlexW4366520888

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.